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Endo2 > Vit D > Flashcards

Vit D Flashcards

1
Q

What stimulates renal 1a-hydroxylase?

A

PTH

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2
Q

What is the active form of vitamin D?

A

1,25 dihydroxycholecalciferol

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3
Q

What is the site of hydroxylation to 25 hydroxycholecalciferol (inactive vitamin D)>?

A

Liver

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4
Q

The renal production of active vitamin D is regulated by what?

A

Plasma parathyroid hormone levels, serum calcium levels, and phosphorus levels

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5
Q

What is second to PTH as a major regularly hormone for Ca++?

A

Vitamin D

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6
Q

Vitamin promotes mineralization of what?

A

New bone

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7
Q

What is the site of major action of vitamin D?

A

Intestine

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8
Q

The intestine induces the synthesis of what>?

A

Calbindin D-28 K

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9
Q

What is a vitamin D dependent calcium binding protein and a cytosol if protein that can bind 4 Ca++

A

Calbindin D-28 K

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10
Q

What two organs increase both Ca++ and phosphate absorption ?

A

Kidney and intestines

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11
Q

What acts synergistically with PTH to stimulate osteoclast activity and bone reabsorption ?

A

Bone

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12
Q

What is a vitamin deficiency in children?

A

Rickets

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13
Q

Insufficient amount of Ca++ and phosphate are available to mineralize glowing bones is a cause of what?

A

Rickets

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14
Q

If it rare for children to develop rickets if there is vitamin D supplementation and adequate sun exposure ?

A

Yes

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15
Q

A vitamin D deficiency in adults causes what?

A

Osteomalacia

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16
Q

When new bone fails to mineralize which leads to the softening of weight bring bones, these are symptoms of what?

A

Osteomalacia

17
Q

What should be measured to determine secondary hyperparathyroidism?

A

Blood 25 (OH) D

(NOT 1,25 (25) D

18
Q

A vitamin D deficiency can lead to what (besides rickets and osteomalacia)

A

Hypocalcemia

19
Q

How can you differentiate secondary hyperparathyroidism from primary?

A

Plasma calcium is low or normal

20
Q

What is the normal range for Blood 25 (OH) D?

A

Between 30-80 no/ml (toxic above 150)

21
Q

Does excessive exposure to sunlight cause vitamin D3 intoxication? **

A

NOOOOOO

22
Q

Exposure of arms and legs for how long a day and between what times are best ?

A

5-30 min and 10 AM and 3 PM

23
Q

What is a good dietary source of vitamin D ?

A

Oily fish

24
Q

In northern latitudes inffufficent UV-B Rays from when to when to produce vitamin D?

A

November to March

25
Q

What is the supplementation of vitamin D from birth to 50?

A

200

26
Q

What is the supplemental recommendation of VIT D from 51-70?

A

400

27
Q

VIT D supplementation after 70?

A

600

28
Q

Vitamin D deficiency is associated with what?

A

Cardiovascular disease, cancer, infection, MS, childhood asthma, tuberculosis, muscle aches, bone pain

29
Q

Does every cell in your body express VIT D receptors

A

Yes

30
Q

What is capable of destroying mycobacterium tuberculosis or LPS?

A

Cathelincidin

31
Q

What are the 3 functions of Vitamin D>?

A

Control inflammation, Muscle strength, blood pressure

32
Q

Vitamin D inhibits what? And causes?

A

Renin (can lead to hypertension)

33
Q

Lack of vitamin D can increase inflammatory factors including what?

A

C reactive protein

34
Q

In chronic renal failure production of active calcium is_______and PTH levels are ________?

A

Low, high

35
Q

What other disease is associated chronic renal failure due do lack of vitamin D?

A

Osteomalacia

36
Q

Calcitonin is synthesized by what?

A

Parafollicular C cells of the thyroid gland

37
Q

Calcitonin gene directs synthesis of what>?

A

Preprocalcitonin

38
Q

Major stimulus for calcitonin secretion is what?

A

Increased plasma Ca++

39
Q

What is the major function of calcitonin ?

A

Inhibit osteoclast if bone reabsorption

Endo2 (4 decks)

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