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PBD FINAL > Viruses I > Flashcards

Viruses I Flashcards

1
Q

RNA dependent RNA polymerase

A

negative strand RNA

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2
Q

reoviridae

A

double strand RNA

-rotavirus

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3
Q

rotavirus

A

has double strand RNA

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4
Q

smallest free living organism

A

mycoplasm

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5
Q

DNA viruses

A 
HHAPPPy
herpes
hepadena
adeno
papova
parvo
pox
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6
Q

parvo

A

single strand DNA

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7
Q

pox

A

dsDNA

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8
Q

orthmyxoviridae

A

RNA virus

-epidemic influenzas

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9
Q

fever, chills, HA, aches, dry cough, sore throat, rhinorrhea

A

influenza

-orthmyxoviridae

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10
Q

structure of orthmyxoviridae

A

spherical - RNA in 8 segments
HA and NA glycoproteins

HA - agglutination of RBCs
NA - cleaves mucin

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11
Q

orthmyxoviridae that invades humans

A

type A

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12
Q

antigenic drift

A

epidemics

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13
Q

antigenic shift

A

pandemics

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14
Q

reyes syndrome

A

children with influenza who take aspirin

-brain and liver problems

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15
Q

bird flu in 1997

A

1997

had diffuse patchy infiltrates with consolidation on chest Xray

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16
Q

new threat for pandemic flu

A

H7N9

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17
Q

spanish flu in 1918

A

H1N1

and 2009

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18
Q

negative single strand RNA
F protein
HA and NA on same spike

A

paramyxoviridae

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19
Q

flu like symptoms with cold and croup, stridor

A

parainfluenza virus

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20
Q

number 1 cause of pneumonia in infants less than 6 months

A

respiratory syncytial virus
RSV

-get giant cells - due to F protein

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21
Q

number 2 cause of lower respiratory illness in children around 1 year old

A

metapneumovirus

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22
Q

parainfluenza virus

A

flu like with cold symptoms and stridor

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23
Q

RSV

A

pneumonia in infants less than 6 month with giant cellsRSV

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24
Q

metapneumovirus

A

lower respiratory illness in children around 1 year old

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25
Q

parotid gland swelling and orchitis

A

mumps

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26
Q

conjunctivitis, photophobia, fever, cough, rhinitis, malaise, followed by spots in mouth and head to toe rash

A

measles

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27
Q

kopliks spots

A

in measles

-red and bluein mouth

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28
Q

complications of measles

A

subacute sclerosing panencephalitis

  • measles in adolescents
  • slow CNS deterioration
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29
Q

measles in adolescents who has slow CNS deterioration

A

subacute sclerosing panencephalitis

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30
Q

RNA hepatitis

A

A, C, D, E, G

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31
Q

DNA hepatitis

A

B

32
Q

fever, aches, jaundice, elevated liver enzymes

A

acute viral hepatitis

33
Q

enlarged tender liver, mild liver enzyme elevation

A

chronic viral hepatitis

with hep B, C, D

34
Q

liver enzymes

A

AST, ALT - hepatocytes

alkaline P, GGT - bile canaliculi

35
Q

acute viral hepatitis in young children

A

hepatitis A

+ RNA icosahedral

36
Q

active hepatitis A infection

A

IgM HAV

37
Q

old hepatitis A infection

A

IgG HAV

38
Q

dane particle

A

hepatitis B

-DNA, icosahedral

39
Q

hepatitis B

A

hospital workers at risk

40
Q

anti HBsAg

A

immunity to hep B

41
Q

HBcAg IgM

A

new hep b infection

42
Q

HBcAg IgG

A

old hep b infection

43
Q

HBeAg

A

high hep b infectivitiy

44
Q

anti-HbeAg

A

low hep b infectivitiy

45
Q

path of hep B

A

acute hepatitis
fulminant hepatitis - liver destruction
chronic hepatitis
-co-infection with hepatitis D

46
Q

hepatitis D

A

co-infection with B

  • superinfection
  • fulminant, chronic, cirrhosis, increased mortality
47
Q

complications of hep B

A

primary hepatocellular carcinoma

48
Q

primary hepatocellular carcinoma

A

with hep B infection increased risk 200x

49
Q

number 1 cause of chronic hepatitis

A

hepatitis C
-RNA icosahedral

IV drug use

50
Q

IV drug use

A

hepatitis C

51
Q

hepatitis in asia, india, africa

A

hepatitis E

52
Q

watery diarrhea, RLQ pain, rose spots, fever

A

salmonella typhi

53
Q

watery diarrhea, RLQ pain, pseudoappendicitis

A

y. enterocolytica

54
Q

localized urethritis with serous mucus discharge

A

ureaplasma urealytica
-normal flora in women

mycoplasm - no cell wall

urea splitter

55
Q

pyelonephritis, urethritis, cystitis, in immunocompromised

A

proteus mirabilis

urea splitter

56
Q

inclusion bodies

A

cytomegalovirus

57
Q

bone marrow vs. AIDS - CMV infection

A

AIDS - eye symptoms

bone marrow - pulmonary symptoms

58
Q

tropics paralytic disease

A

HTLV-1

59
Q

HIV-1

A

US

60
Q

HIV-2

A

west africa

61
Q

p24

A

capsid of HIV

-used for diagnosis

62
Q

gp160

A

HIV

  • binds CD4
  • consists of gp120 and gp41
63
Q

env gene

A

in HIV

-gp120 hypervariable region

64
Q

decreased CCR5

A

resistant to HIV

65
Q

stages of HIV infection

A

1 - acute viral illness
2 - clinical latency
3 - AIDS

66
Q

acute viral illness with HIV

A

viremia, fever, malaise, lymphadenopathy, pharyngitis

67
Q

clinical latency with HIV

A

gradual CD4 T cell destruction

-no symptoms

68
Q

AIDS

A 
T cell < 200
-or opportunistic infections:
candida albicans
pneumocystic cartnii
kaposi sarcoma
69
Q

HIV count measures

A

speed of infection

70
Q

CD4 count measures

A

progression of infection

71
Q

multinucleated giant cells

A

in HIV - transmission of HIV with T cell fusion

72
Q

hypergammaglobulinema

A

can be seen in AIDS

73
Q

constitutional illness

A

AIDS

-sweats, fever, lymph node swelling, weight loss, wasting

74
Q

malignancies with AIDS

A

B cell lymphoma - brain mass
kaposi sarcoma - HHV-8 co-factor - red purple nodules on skin all over body
invasive cervical squamous cell carcinoma

75
Q

B cell lymphoma

A

AIDS patients

-mass in brain

76
Q

kaposi sarcoma

A

red purple nodules on skin all over body

  • AIDS patients
  • associated with HHV-8 cofactor

PBD FINAL (10 decks)

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