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Immunology Block > Viruses and Viral Life Cycle > Flashcards

Viruses and Viral Life Cycle Flashcards

1
Q

What are the functions of the capsid protein?

A
  1. Protect viral nucleic acid from stress
  2. Interact specifically with viral nucleic acid for packaging
  3. Interact with host receptors to allow entry
  4. Allow for release of nucleic acid upon entry
  5. Assist in the processes of viral and/or host gene regulation
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2
Q

What are the six steps of the viral life cycle?

A
  1. Attachment
  2. Entry
  3. Uncoating
  4. Synthesis of protein and nucleic acid
  5. Assembly
  6. Release
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3
Q

Does HIV have a capsid, nucleocapsid, or both?

A

both

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4
Q

Describe icosahedral protein coats

A

They are spherical and nucleic acid is limited by the size of the coat

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5
Q

Describe helical protein coats

A

They are rod shaped and nucleic acid is not limited

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6
Q

Are rotavirus, noravirus, and enterovirus enveloped or nonenveloped?

A

They are nonenveloped because they are in the GI tract

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7
Q

Are DNA or RNA virus better at latency?

A

DNA

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8
Q

Hepatitis viruses are all ____ types of viruses that have ____ genome type

A

different; different

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9
Q

What are the five important Herpesviruses to know?

A
  1. HSV-1
  2. HSV-2
  3. Varicella-Zoster Virus (VZV)
  4. Cytomegalovirus (CMV)
  5. Epstein-Barr Virus (EBV)
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10
Q

The herpesviruses have a ____ genome, _____ capsid coat, and ____ an envelope

A

dsDNA; isocahedral; have

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11
Q

What is the primary infection of HSV-1 and HSV-2?

A

gingivostomatitis and genital herpes

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12
Q

What is the reactivation infection of HSV-1 and HSV-2?

A

cold sore and genital herpes

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13
Q

What is the primary infection of Varicella-Zoster virus?

A

chickenpox

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14
Q

What is the reactivation reaction of VZV?

A

shingles

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15
Q

What are the two viruses with segmented ssRNA?

A

Influenza A and rotavirus

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16
Q

What is the eclipse-period of the virus?

A

no intracellular virions are detected

17
Q

What is progeny nucleocapsid formation?

A

accumulation of structural proteins in the same cellular compartment where replication of progeny genomes occurs

18
Q

Maturation is an additional step required for what kind of virus?

A

enveloped

19
Q

What is the cytopathic effect?

A

alteration of the appearance or death due to the effects of viral replication

20
Q

What are lentiviruses?

A

retroviruses that can infect a non-dividing cell (HIV)

21
Q

What are the two main proteins involved in the adsorption and entry of HIV into the cell?

A

GP120 binds to the CD4 receptor allowing GP41 to interact with CCR5 or CXCR4

22
Q

What is the main capsid protein of HIV?

A

p24

23
Q

What are the three enzymes carried by HIV?

A

Reverse transcriptase, integrase, protease

Immunology Block (7 decks)

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