Immunosuppressants

Question 1

What is the function of eiconsanoids?

Answer 1

Act as local vasodilators in inflammation

Question 2

What cells produce prostaglandins?

Answer 2

many different types

Question 3

What cells produce thromboxanes?

Answer 3

platelets

Question 4

What cells produce leukotrienes?

Answer 4

leukocytes

Question 5

What does COX-1 do?

Answer 5

Constitutively expressed for homeostatic functions

Question 6

What does COX-2 do?

Answer 6

Inducibly expressed for inflammatory response

Question 7

What is one of the major role of prostaglandins?

Answer 7

Produce and promote mucous layer in the GI tract

Question 8

What does thromboxanes promote?

Answer 8

Platelet activation

Question 9

What do NSAIDs inhibit?

Answer 9

prostaglandins and thromboxanes

Question 10

What is unique about aspirin as an NSAID?

Answer 10

it irreversibly inhibits COX 1/2 through covalent modification

Question 11

What is Kawasaki disease?

Answer 11

Immune disorder of unknown function with fever, conjunctivitis, swollen lymph nodes, swollen hands/feet, rash, and changes in oral mucosa

Question 12

How do you treat Kawasaki disease?

Answer 12

Aspirin and IVIG

Question 13

What are the off-label uses of aspirin?

Answer 13

Kawasaki disease, pre-eclampsia, colorectal cancer

Question 14

What is Reye’s syndrome?

Answer 14

serious and often fatal disease caused by treating children with aspirin while they have viral infections

Question 15

What does it mean to have aspirin-sensitive asthma?

Answer 15

COX inhibition reroutes AA to make leukotrienes which cause bronchoconstriction

Question 16

Who normally suffers from acute aspirin poisoning?

Answer 16

Children because OD > 150 mg

Question 17

What is the major advantage of Naproxen?

Answer 17

It has a longer half-life than ibuprofen

Question 18

Where are ibuprofen and naproxen retained in the body?

Answer 18

They bind well to albumin so they are retained in the blood plasma

Question 19

What kind of drugs are COX-2 inhibitors?

Answer 19

Celecoxib (celebrex) and Rofecoxib (vioxx)

Question 20

What does Celecoxib inhibit?

Answer 20

COX-2

Question 21

What does Rofecoxib inhibit?

Answer 21

COX-2

Question 22

Why do COX-2 inhibitors cause more cardio problems?

Answer 22

They also inhibit prostacyclins, which are anti-clotting

Question 23

What does ibuprofen inhibit?

Answer 23

COX-1/2

Question 24

What does aspirin inhibit?

Answer 24

COX-1/2

Question 25

What does naproxen inhibit?

Answer 25

COX-1/2