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2 - BOD > Viruses > Flashcards

Viruses Flashcards

1
Q

IFNα/β

A

Released by infected cells
Stimulate antiviral state in neighbouring cells via JAK-STAT pathway
(ISGF binds ISRE - stimulates antiviral protein production)

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2
Q

Latency in herpesviruses

A

All herpesviruses can form latent infections
VZV: latent in sensory ganglia neurons
HCMV: monocytes (reactivate upon differentiation to macrophages)

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3
Q

Papovaviruses

A

dsDNA, icosahedral, no envelope

HPV 16/18 cause cervical carcinoma

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4
Q

Adenoviruses

A

dsDNA, icosahedral, no envelope

Adenoviruses causes acute respiratory disease

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5
Q

Herpesviruses

A 
dsDNA, icosahedral, enveloped 
HSV - cold sores/genital warts (1/2)
VZV - chicken pox and shingles
EBV - glandular fever and Burkitt lymphoma
HMCV
HHV8 - Kaposi's sarcoma
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6
Q

Poxviruses

A

dsDNA, complex capsid, enveloped
Variola virus - smallpox
Vaccinia virus - vaccine against smallpox
Replicated in the nucleus

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7
Q

Parvoviruses

A

ssDNA, icosahedral, no envelope

Blue tongue virus

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8
Q

Picornaviruses

A 
\+ve sense ssRNA, icosahedral, no envelope
Poliovirus - poliomyelitis
Hepatitis A - acute hepatitis
Rhinovirus - common cold
FMDV
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9
Q

Togaviruses

A

+ve sense ssRNA, icosahedral, enveloped

Rubella virus

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10
Q

Flaviviruses

A

+ve sense ssRNA, icosahedral, enveloped
Hepatitis C - (acute and) chronic hepatitis
Yellow fever - haemorrhagic fever (jaundice)

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11
Q

Coronaviruses

A

+ve sense ssRNA, helical, enveloped

SARS

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12
Q

Orthomyxoviruses

A

Segmented (8) -ve sense ssRNA, helical, enveloped

Influenza A virus

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13
Q

Paramyxoviruses

A

-ve sense ssRNA, helical, enveloped
Measles
Mumps

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14
Q

Rhabdoviruses

A

-ve sense ssRNA, helical, enveloped

Rabies

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15
Q

Filoviruses

A

-ve sense ssRNA, helical, enveloped

Ebola virus

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16
Q

Retroviruses

A

+ve sense ssRNA (DNA intermediate), 100nm capsid, enveloped
HIV - AIDS
FLV - leukaemia in cats
RSV - sarcoma in fowls

17
Q

Hepadnaviruses

A

dsDNA (RNA intermediate), icosahedral, enveloped

Hepatitis B

18
Q

Live attenuated vaccines

A 
Yellow fever
MMR
Polio (Sabin)
VZV
Pseudorabies
Rinderpest
Hepatitis A
19
Q

Live related virus vaccines

A

Variola

Marek’s Disease

20
Q

Dead (inactivated) vaccines

A 
Hepatitis A
Polio (Salk)
Rabies
Hepatitis B
FMDV
Influenza
HPV
21
Q

Passive ‘vaccines’ (immunisation)

A 
Rabies (post exposure)
Hepatitis B (post exposure in neonates)

2 - BOD (5 decks)

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