Fungi Flashcards
1
Q
Dectin-1
A
PRR, detects β-1,3-glucans
2
Q
Fungal response
A
Mediated via syk → NF𝜅B
IL-1β/IL-6/IL-23 production (inflammasome) - TH17 response (IL-17, neutrophils)
IL-12/TNFα - TH1 response
3
Q
Impaired IL-17 immunity
A
Chronic superficial candida infections
4
Q
Impaired neutrophil immunity
A
Predisposes deep fungal infections
5
Q
Impaired T-cell/macrophage immunity
A
Superficial/deep yeast infection
6
Q
Histoplasma capsulatum
A
Systemic pathogen, inhaled and germinates into budding yeasts
Express camouflage glucan (isn’t detect by PRRs)
7
Q
Candida albicans
A
Systemic opportunist commensal yeast
8
Q
Cryptococcus neoformans
A
Systemic opportunist
Thick polysaccharide capsule important virulence factor
Tendency to spread to the CNS and cause meningo-encephalitis
