Virus Flashcards
Largest DNA virus a. Parvovirus
b. Adenovirus
c. Herpesvirus
d. Poxvirus
D
Viral infectivity is generally destroyed by heating at
a. 50-60 degree Celsius for 30 mins
b. 50-60 degree Celsius for 30-60 mins
c. 37 degree Celsius for several hours
d. 37 degree Celsius for 30 mins
A
The following are true of viruses except
a. Some viruses are potential bioterrorism agents based on ease of host-to-host transmission and
mortality rates
b. All infections lead to newly progeny virus
c. Known viruses are highly diverse, varying in size, shape and genetic content, some types possess a lipid envelope.
d. Viruses are the smallest infectious agents and contain only one type of nucleic acid (DNA or RNA)
B
Virus-infected cells often develop morphologic changes referred to as cytopathic effects. Which of the following statements about virus induced cytopathic changes is most accurate?
a. They are rarely associated with cell death
b. They can only be seen with an electron microscope
c. They are pathognomonic for an infecting virus
d. They may include giant cell formation
D
Some viruses are characterized by helical symmetry of the viral nucleocapsid. Which of the following statements about viruses with helical symmetry is most accurate?
a. Excess empty helical particles containing no nuclei acid are commonly produced in infected cells
b. All enveloped viruses with helical symmetry are classified into the same virus family
c. All human viruses with helical nucleocapsids possess an envelope
d. Helical nucleocapsids are found primarily in DNA-containing viruses
C
Icosahedral enveloped RNA virus
a. Togavirus
b. Flavivirus
c. Coronavirus d. Bunyavirus
A
The mode of transmission of this virus is thru direct contact through the mouth
a. Hepatitis B
b. Rubella virus
c. Mumps virus
d. Cytomegalovirus
D
Smallest RNA virus a. Picornavirus
b. Filovirus
c. Coronavirus
d. Calicivirus
D
The following are used as a basis for the classification of viruses except
a. Virion morphology, including size, type of symmetry, presence or absence of peplomers, and
presence or absence of membranes
b. Antigenic properties, particularly reactions to various antigens
c. Virus genome properties including type of nucleic acid (DNA or RNA), size of the genome, strandedness (single or double), whether linear or circular, sense (positive, negative, ambiense) segments (number, size), nucleotide sequence, percent GC content and presence of special features (repetitive elements, isomerization)
d. Biologic properties, including natural host range, mode of transmission, vector relationships, pathogenicity, tissue tropisms, and pathology.
B
Described as very long and threadlike and causes severe hemorrhagic fever in Africa
a. Filoviridae
b. Paramyxoviridae c. Orthomyxoviridae d. Reoviridae
A
following are naked icosahedral nucleocapsid RNA virus except a. Picornavirus
b. Flavivirus
c. Reovirus
d. Calicivirus
B
Viruses belonging to which of the following groups are likely to establish latent infections
a. Influenza viruses
b. Poxviridae
c. Herpesviruses
d. Filoviruses
C
DNA virus which is icosahedral capsid and is sensitive to Ether sensitivity a. Adenovirus
b. Hepadnavirus
c. Parvovirus
d. Herpesvirus
B
The following are DNA viruses except a. Adenovirus
b. Poxvirus
c. Picornavirus
d. Hepadnavirus
C
Which of the following virus described as double stranded RNA virus? a. Flaviviridae
b. Togaviridae
c. Caliciviridae
d. Picornaviridae
D
Which RNA virus helical, capsid, enveloped virion and is sensitive to Ether sensitivity? a. Paramyxoviridae
b. Orthomyxoviridae
c. Reoviridae
d. Picornaviridae
B
he following describes nucleocapsid
a. The protein-nucleic acid complex representing the packaged form of the viral genome
b. Are usually a collection of more than one nonidentical protein subunit
c. Morphologic units seen in the electron microscope on the surface of icosahedral virus particles
d. The protein shell, or coat that encloses the nucleic acid genome
A
The only enveloped DNA virus a. Parvovirus
b. Adenovirus
c. Herpesvirus
d. Hepadnavirus
D
his viruses are usually stable between pH values of 5.0 and 9.0
a. Cardioviridae
b. Hepatitis virus
c. Adenovirus
d. Enteroviridae
D
Which of the following RNA virus is resistant to Ether sensitivity? a. Orthomyxoviridae
b. Paramyxoviridae
c. Picornaviridae
d. Reoviridae
C
All of the following are cardinal signs of measles, except
a. Diarrhea
b. Conjunctivitis c. Coryza
d. Cough
A
At what temperature should clinical specimens suspected of containing viruses kept for transport that takes days?
a. -1 C b. 40C c. -70C d. 37C e. 24C f. 0 C
F
The most common viral syndrome of pericarditis, myocarditis, and pleurodynia is caused by
a. Epstein Barr virus
b. Coxsackie B virus
c. Herpes simplex virus
d. Respiratory syncytial virus
B
Which of the following spikes of influenza virus binds to the cell surface receptors to initiate infection of the cell?
a. Gp 120 and 40
b. Hemagglutinin
c. Fusion spikes
d. Neuraminidase
B
A third year medical student complained of sore throat and extreme fatigue. The resident physician noted lymphadenopathy and ordered a rapid test for infectious mononucleosis antibodies that was negative. Bacterial cultures were negative as were serological tests for influenza A and B, HIV-1, CMV, Hepatitis B, and anti-streptolysin O. what would be the next line of viral testing to establish a diagnosis? A. Rubella
B. EpsteinBarr
C. WestNile
D. Herpessimplexvirus
B
Owl’s eye appearance inclusions are seen in
a. Herpes simplex virus infections
b. Epstein Barr virus infection
c. Adenovirus infection
d. Cytomegalovirus infections
D
The Sabin polio vaccine uses which of the following?
a. Recombinant viral antigens
b. Formalin-inactivated viruses
c. Attenuated virus
d. DNA
D
Which of the following has not been successfully used to detect viruses in clinical specimens?
a. Growth on selective media
b. Cytopathic effect
c. ELISA
d. Immunofluorescent antibody test
A
Which of the following statements about Hepatitis C is true?
a. Most common indication for liver transplant
b. Does not cause liver cancer
c. DNA virus
d. Does not cause coinfection with hepatitis B
A
From which part of the virus is the enveloped acquired?
a. Capsomeres or genomes
b. Nuclear or cytoplasmic membrane
c. Nucleus or cytoplasm
d. mRNA or DNA
B
mother delivers a baby three days after developing chickenpox. Which of the following is true?
a. Baby has a risk of congenital Varicella infection
b. Give no treatment to mother and give antiviral treatment to baby
c. No risk to both mother and baby
d. Give antibody treatment to mother
A
Which of the following opportunistic disease is NOT closely associated with AIDS? a. Tuberculosis
b. Cryptococcus
c. Cryptosporidiosis
d. Malaria
D
A 36 year old father complained of rash on his torso. His children had been diagnosed with chickenpox and confined to their home. The father had experienced chickenpox as a child and knew he did not have the same rash as his children. What is the most likely cause of the father’s rash?
a. HSV-2
b. Varicella-zoster
c. Epstein Barr
d. HSV-1
B
A 5 year old girl was admitted to the hospital following a 2-day visit with relative over New Year Holidays. Vomiting and diarrhea left the child severely dehydrated. No other members of the family were affected. Bacterial cultures proved negative. A stool sample should be tested for which virus?
a. CMV
b. Hepatitis A
c. Rotavirus
d. EBV
C
A child is presented with fever, conjunctivitis and bluish-white spot on buccal mucosa. Four days later, she developed rashes. What is the characteristic feature of the virus that is responsible for this condition?
a. ds-enveloped RNA virus
b. ss- naked RNA virus
c. ss-enveloped RNA virus
d. ds-naked RNA virus
C
The type of cell culture that best supports the growth of CMV is
a. HeLa cells
b. Hep-2 cells
c. Human fibroblast cells
d. Primary monkey kidney cells
C
female became pregnant after 1 month of having MMR vaccine, though was advised to avoid pregnancy. What advice the doctor should give to the patient?
a. Low risk, no action needed
b. Termination of pregnancy is mandatory
c. Wait and watch
d. High risk of anomalies, serious consideration for termination
C
Which of the following is an RNA virus that has nuclear phase to its replication process? a. Rhabdovirus
b. Coronavirus
c. Togavirus
d. Retrovirus
D
Which serologic markers of hepatitis B can differentiate chronic active and chronic carrier patients? a. Anti-HBs
b. Anti-HBc c. HBsAg d. HBeAg
D
Which of the following statement of clinical viral disease is true?
a. It usually follows viral infection
b. It is most frequently due to toxin production
c. It can result without infection of host cells
d. It is associated with target organs in most disseminated viral disease
D
Which of the following statement is/are true of all paramyxoviruses?
a. They contain a single stranded RNA genome of negative polarity
b. Enveloped is derived from the host cells plasma membrane
c. They have a cytoplasmic site of replication
d. All of the above
e. None of them
D
. A very small, single stranded DNA virus that causes a febrile illness with a rash and it is called the fifth childhood disease after rubella, rubeola, varicella and roseola is
a. Adenovirus
b. Parvovirus B19
c. Coxsackie A virus
d. Rotavirus
B
An 8 year old boy was admitted to SWUMC with a diagnosis of viral encephalitis. History revealed that the boy harbored stray cat from a nearby parks. What is the best method to determine if the boy has contracted rabies?
a. Request immunofluorescent test for antigen in cutaneous nerve obtained by nuchal biopsy
of the patient
b. Remove the brain stem from the cat and examine cytopathic effects
c. Request immunofluorescent test for antibody on the saliva from the cat
d. Isolate the virus from the saliva of both the cat and the patient
A
The serological test of a patient shows HBsAg negative, IgM anti HBc antibody negative, HBV DNA not detectable, anti-Hbc IgG antibody positive and anti HBs antibody positive. What is the most probable diagnosis?
a. Chronic hepatitis with pre-core mutant
b. Chronic hepatitis in active stage
c. Recovery from previous infection of hepatitis B
d. Acute hepatitis window period
C
Which of the following terms refers to the exchange of homologous segments of RNA between two different influenza type A viruses?
a. Phenotypic mixing
b. Phenotypic making
c. Genetic reassortment
d. Complementation
C
Which of the following is a virus infection involving the presence of a noninfectious form of the virus? a. Persistent
b. Subclinical
c. Latent
d. Abortive
C
Which of the following pair of viruses are the most common cause of viral pneumonia in adults?
a. Hepatitis A and B viruses
b. Influenza and adenovirus
c. Coxsackie A and B viruses
B
Which of the following is NOT associated with herpes simplex virus?
a. Cold sores
b. Thrush
c. Encephalitis
d. Genital herpes
B
Which virus is associated with venereal and respiratory warts and produce lesions of skin and mucous membrane?
a. Polymavirus
b. Adenovirus
c. Pox virus
d. Papilloma virus
D
Which specimen should be collected from a patient suspected with enteroviral meningitis?
a. Throat swab
b. Stool
c. CSF
d. All of the choices
D
Which of the following of viral hepatitis infection in pregnancy, the maternal mortality is highest?
a. Hepatitis B
b. Hepatitis A
c. Hepatitis C
d. Hepatitis E
D
Culex tritaeniorhynchus is vector of which viral disease?
a. Malaria
b. Yellow fever
c. Japanese encephalitis
d. Dengue
C
The appearance of Koplik spots in the mucosa of patients is characteristic of infection with viral what agent?
a. Variola
b. Rubeola
c. Varicella d. Rubella
B
47 year old woman who has rheumatoid arthritis and treated with a tumor necrosis factor (TNF) antagonist notice many umbilicated papules on the skin of her upper thighs. What is the most likely causative agent?
a. MCV
b. Variola c. HHV6 d. HSV2
A
mature virus particle containing a nucleic acid core surrounded by a protein coat with or without envelope is called a
a. Capsomere
b. Virion
c. Nucleocapsid d. Genome
B
All are correct statement about Hepatitis A except
a. It is difficult to culture
b. It belongs to enterovirus
c. Vaccines are available
d. Chronicity is the hallmark of the disease
D
Mumps is characterized by an infection of the
a. Cranial nerve VII
b. Pancreas
c. Parotid
d. Central nervous system
e. Thymus
C
. A cervical Papanicolaou smear is taken from a woman with vaginal papilloma (wart). Certain type of papillomas have been associated with cervical carcinoma. What method or methods would be used to detect and identify the type of papilloma in the cervical smear?
a. Immunofluorescent staining
b. Cell culture
C. ELISA and EIA
d. PCR analysis
D
Which of the following statements is true about localized viral disease?
a. It may have systemic clinical feature such as fever
b. It is associated with pronounced viremia
c. It is major feature of congenital viral infections
d. It can be associated with carrier individuals
A
