Virology Exam 3 Flashcards
1
Q
reservoir
A
does not show symptoms, persistent infection
2
Q
zoonoses
A
diseases that cross over into humans from animals
3
Q
influenza genome
A
- eight genome segments code for a total of 11 different proteins
- nine of proteins are packaged into viral particles
- each gene is on own piece of RNA
4
Q
influenza infection
A
- of the respiratory tract can lead to secondary bacterial infections
- initially infects and causes a loss of ciliated epithelium and disrupts mucociliary flow
- induces production of interferons and cytokines
5
Q
hemagglutinin protein (H of H1N1) for influenza
A
- binds cells receptors and mediates fusion of envelope with endosomal membrane
- binds to sialic acid residues on muco-proteins
- if silica acid not cut off, then it will not be infectious
6
Q
antigenic drift
A
slow, continuous accumulation of point mutations
- changing in cell surface receptors
7
Q
antigenic shift
A
results from reassortment of genes during mixed infection with two or more subtypes
8
Q
serotypes
A
numbers in H1N1, detected using an antibody
9
Q
pandemic
A
epidemic that spread to large geographic region
10
Q
What drugs are being stockpiled in the case of a influenza A H5N1 pandemic?
A
- zanamivir
- oseltamivir (tamiflu)
11
Q
triple reassortant
A
3 viruses in same host at same time
12
Q
How many influenza viruses are put into a vaccine?
A
3
