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Virology Flashcards

1
Q

Live attenuated vaccines

A

Yellow fever
Chicken pox
Sabin polio
MMR

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2
Q

Killed vaccines

A

Rabies
Influenza
Polio salk
Hepa A

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3
Q

Recombinant vaccine

A

Hepa b

HPV

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4
Q

All DNA virus double stranded except

A

Parvovirus

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5
Q

All DNA are icosahedral and replicate in nucleus except

A

Pox virus

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6
Q

Naked DNA viruses

A

Parvovirus
Adenovirus
HPV

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7
Q

Slapped cheek dse

A 
Erythema infectiosum (5th dse)
Parvovirus b19
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8
Q

Causes aplastic crises in pt with sickle cell anemia, thalassemia, spherocytosis

A

Parvovirus B19

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9
Q

Chronic B19 infection causes

A

Pancytopenia

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10
Q

Only virus with fiber - penton fiber

A

Adenovirus

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11
Q

MCC of viral conjunctivitis

A

Adenovirus

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12
Q

Cowdry type b nuclear inclusions

A

Adenovirus

Poliovirus

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13
Q

Cytopathic effect of HPV

A

Koilocytes

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14
Q

MC viral STD

A

Genital warts condyloma accuminata due to HPV 6,11

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15
Q

Causes carcinoma of cervix, penis, anus, vulva

A

HPV 16, 18, 31, 33

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16
Q

Ttt for condyloma accuminata

A

Podophyllin

Imiquimod

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17
Q

Causes progressive multifocal leukoencephopathy

A

JC Polyoma virus

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18
Q

Enveloped DNA viruses

A

Herpes viruses

HHV 8

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19
Q

Herpesvirus

A

CMV
HSV
EBV
VZV

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20
Q

Latent site of HSV 1

A

Trigeminal ganglia

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21
Q

Latent site of HSV 2

A

Lumbosacral ganglia

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22
Q

Multinucleated cells on Tzanck smear

A

HSV

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23
Q

Cowdry type A

A

HSV

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24
Q

Temporal lobe encephalitis

A

HSV 1

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25
Q

DOC of HSV

A

Acyclovir

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26
Q

HSV 2 spectrum of dse

A

Genital herpes
Neonatal herpes
Aseptic meningitis

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27
Q

Latent site of VZV

A

Dorsal root ganglia

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28
Q

Multinucleated giant cells with intranuclear inclusions

A

VZV

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29
Q

Facial nerve paralysis due to involvement of geniculate ganglion; VZV

A

Ramsay hunt syndrome

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30
Q

Giant cells with owl’s eye inclusions

A

CMV

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31
Q

Impair assembly of MHC class 1 viral peptide complex

A

CMV

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32
Q

MCC of congenital abnormalities

A

CMV

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33
Q

Heterophil neg mononucleosis

A

CMV

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34
Q

MCC of blindness in AIDS

A

CMV retinitis

CD4

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35
Q

DOC for CMV

A

Gancyclovir

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36
Q

Causes blueberry muffin lesion

A

CMV
Rubella
Disseminated neuroblastoma

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37
Q

Malignancy of vascular endothelial cells

A

Kaposi sarcoma

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38
Q

Largest viruses

A

Small pox

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39
Q

Guarneri bodies

Intracytoplasmic eosinophilic inclusions

A

Small pox

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40
Q

Henderson peterson bodies

A

Molluscum contagiosum

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41
Q

Ttt for molluscum contagiosum

A

Cifodovir

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42
Q

Assoc with autoimmune vasculitides

Polyarteritis nodosa

A

Hepa viruses

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43
Q

Ttt for hepatitis

A

Interferon alpha

Lamivudine

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44
Q

All RNA viruses are single stranded except

A

Rotavirus (Reovirus)

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45
Q

Picornaviridae

PERCH

A 
Polio
Echo
Rhino
Coxsackie
Hep A
46
Q

Affects motor neurons in ant horn of SC causing flaccid paralysis

A

Poliovirus

47
Q

Most common clinical form of poliovirus

A

Abortive poliomyelitis

48
Q

Causes herpangina, hand foot and mouth dse. Hemorrhagic conjunctivitis

A

Coxsackie A

49
Q

MCC of viral myocarditis

A

Coxsackie B

50
Q

MCC of aseptic meningitis

A

Enteroviruses -Coxsackie

51
Q

Most important test for Hepa A

A

Anti HAV IgM

52
Q

Also known as enterovirus 72

A

Hepa A virus

53
Q

Hepa virus high mortality in pregnant

A

Hepa E (caliciviridae)

54
Q

MCC of nonbacterial GE in adults

A

Norwalk virus (norovirus)

55
Q

MCC of childhood diarrhea

56
Q

Naked RNA

CPR

A

Picorna
Calici
Reo

57
Q

Major antigens of influenza

A

Hemagglutinin

Neuroaminidase

58
Q

MCC of RT infections

59
Q

Degrades protective layer of mucus in RT found in influenza

Cleaves sialic acid to release virus progeny

A

Neuraminidase

60
Q

Initiates infection of cell by influenza

Neutralized by antibody

A

Hemagglutinin

61
Q

Antigenic shifts causing pandemics

A

Influenza A

62
Q

Epidemics due to antigenic drifts

A

Influenza B

63
Q

DOC for influenza

A

Oseltamivir

Zanamivir

64
Q

DOC for influenza A

A

Amantadine

Rimantidine

65
Q

Paramyxoviruses

Envelope spikes

A

Parainfluenza
RSV
Measles
Mumps

66
Q

Warthin finkleday bodies

67
Q

SOD of mumps

A

Parotitis
Orchitis
Meningitis

68
Q

Most Impt cause of pneumonia and bronchiolitus in infants

69
Q

Ttt for RSV

70
Q

Causes croup with steeple sign

Inspiratory stridor

A

Parainfluenza 1 and 2

71
Q

Ttt for croup

A

Racemic epinephrine

72
Q

Bullet shaped enveloped virus

A

Rabies virus

73
Q

Cause of early death in rabies

A

Early brainstem encephalitis

74
Q

Virus with club shaped spikes

A

Coronavirus

75
Q

Reservoir horseshoe bat

Intermediate host civet cat

A

Corona virus

76
Q

Atypical pneumonia progressing to ARDS

77
Q

In SARS, coronavirus attaches to what receptor

A

Ace 2 receptor

78
Q

Non cavitary ground glass infiltrates

79
Q

Breakbone fever

A

Dengue virus (flaviviridae)

80
Q

Most prevalent blood borne antigen

A

Hepatitis C (flavivirus)

81
Q

Dx test for hepa C

A

Anti HVC

HVC Rna

82
Q

With liver specific microRNA

A

Hepatitis C

83
Q

Hepatitis with highest chronic carrier rate

A

Hepatitis C

84
Q

Main cause of essential mixed cryoglobulinemia

A

Hepatitis C

85
Q

MC indication for liver transplantation

A

Hepatitis C

86
Q

3 day rash with post LAD

A

Rubella (togaviridae)

87
Q

Immune complex polyarthritis in adults

A

Rubella (togaviridae)

88
Q

Congenital rubella syndrome assoc abnormalities

A 
PDA 
Blueberry muffin rash
Sensorineural hearing loss
Cataracts
MR
89
Q

Converts single strand RNA to double strand dna

A

Reverse transcriptase

90
Q

Major capsid protein in HIV
Serologic marker
Located in core

91
Q

HIV fusion protein with host cell

92
Q

HIV attachment protein interacts with CD4

Rapid change in antigenicity

93
Q

Directs entry of DNA provirus to nucleus

Essential for viral assembly

94
Q

Structural HIV genes

95
Q

Regulatory gene in HIV

Activation of transcription of viral genes

96
Q

Regulatory gene in HIV that decreases CD4 and class 1 MHC proteins

97
Q

Phase of seroconversion in HIV

98
Q

Cause of chronic diarrhea in aids

99
Q

Aids illnesses CD4

A

CMV retinitis
M. Avium pulmo dse
Histoplasmosis

100
Q

Aids illnesses CD4

A

Disseminated Tb
HSV esophagitis
Esophageal candidiasis
Kaposi’s sarcoma

101
Q

Aids illnesses CD4

A 
PCP pneumonia
Cerebral toxoplasmosis
Cryptococcus meningoenceph
Coccidiomycoses - c. Immitis
Chronic diarhhea - c. Parvum
102
Q

For HIV prognostication

103
Q

HAART

A

Two nucleoside inhibitors
Zidovudine lamivudine

Protease inhibitor
Indinavir

104
Q

Retrovirus causing adult t cell leukemia and myelopathy

105
Q

Malignant t cells with flower shaped nucleus

106
Q

Thread like viruses

Longest viruses

107
Q

Flavivirus
Bird mosquito man cycle
Neuroinvasive dse

A

West nile virus

108
Q

MCC of epidemic encephalitis

A

Japanese B encephalitis

109
Q

Jap B virus transmitted by

110
Q

Jap B enceph on CT scan

A

Thalamuc infarcts

111
Q

Only live vaccine given to AIDS

Micro (9 decks)

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