Virology Flashcards
1
Q
Live attenuated vaccines
A
Yellow fever
Chicken pox
Sabin polio
MMR
2
Q
Killed vaccines
A
Rabies
Influenza
Polio salk
Hepa A
3
Q
Recombinant vaccine
A
Hepa b
HPV
4
Q
All DNA virus double stranded except
A
Parvovirus
5
Q
All DNA are icosahedral and replicate in nucleus except
A
Pox virus
6
Q
Naked DNA viruses
A
Parvovirus
Adenovirus
HPV
7
Q
Slapped cheek dse
A
Erythema infectiosum (5th dse) Parvovirus b19
8
Q
Causes aplastic crises in pt with sickle cell anemia, thalassemia, spherocytosis
A
Parvovirus B19
9
Q
Chronic B19 infection causes
A
Pancytopenia
10
Q
Only virus with fiber - penton fiber
A
Adenovirus
11
Q
MCC of viral conjunctivitis
A
Adenovirus
12
Q
Cowdry type b nuclear inclusions
A
Adenovirus
Poliovirus
13
Q
Cytopathic effect of HPV
A
Koilocytes
14
Q
MC viral STD
A
Genital warts condyloma accuminata due to HPV 6,11
15
Q
Causes carcinoma of cervix, penis, anus, vulva
A
HPV 16, 18, 31, 33
16
Q
Ttt for condyloma accuminata
A
Podophyllin
Imiquimod
17
Q
Causes progressive multifocal leukoencephopathy
A
JC Polyoma virus
18
Q
Enveloped DNA viruses
A
Herpes viruses
HHV 8
19
Q
Herpesvirus
A
CMV
HSV
EBV
VZV
20
Q
Latent site of HSV 1
A
Trigeminal ganglia
21
Q
Latent site of HSV 2
A
Lumbosacral ganglia
22
Q
Multinucleated cells on Tzanck smear
A
HSV
23
Q
Cowdry type A
A
HSV
24
Q
Temporal lobe encephalitis
A
HSV 1
25
DOC of HSV
Acyclovir
26
HSV 2 spectrum of dse
Genital herpes
Neonatal herpes
Aseptic meningitis
27
Latent site of VZV
Dorsal root ganglia
28
Multinucleated giant cells with intranuclear inclusions
VZV
29
Facial nerve paralysis due to involvement of geniculate ganglion; VZV
Ramsay hunt syndrome
30
Giant cells with owl's eye inclusions
CMV
31
Impair assembly of MHC class 1 viral peptide complex
CMV
32
MCC of congenital abnormalities
CMV
33
Heterophil neg mononucleosis
CMV
34
MCC of blindness in AIDS
CMV retinitis
| CD4
35
DOC for CMV
Gancyclovir
36
Causes blueberry muffin lesion
CMV
Rubella
Disseminated neuroblastoma
37
Malignancy of vascular endothelial cells
Kaposi sarcoma
38
Largest viruses
Small pox
39
Guarneri bodies
| Intracytoplasmic eosinophilic inclusions
Small pox
40
Henderson peterson bodies
Molluscum contagiosum
41
Ttt for molluscum contagiosum
Cifodovir
42
Assoc with autoimmune vasculitides
| Polyarteritis nodosa
Hepa viruses
43
Ttt for hepatitis
Interferon alpha
| Lamivudine
44
All RNA viruses are single stranded except
Rotavirus (Reovirus)
45
Picornaviridae
| PERCH
```
Polio
Echo
Rhino
Coxsackie
Hep A
```
46
Affects motor neurons in ant horn of SC causing flaccid paralysis
Poliovirus
47
Most common clinical form of poliovirus
Abortive poliomyelitis
48
Causes herpangina, hand foot and mouth dse. Hemorrhagic conjunctivitis
Coxsackie A
49
MCC of viral myocarditis
Coxsackie B
50
MCC of aseptic meningitis
Enteroviruses -Coxsackie
51
Most important test for Hepa A
Anti HAV IgM
52
Also known as enterovirus 72
Hepa A virus
53
Hepa virus high mortality in pregnant
Hepa E (caliciviridae)
54
MCC of nonbacterial GE in adults
Norwalk virus (norovirus)
55
MCC of childhood diarrhea
Rotavirus
56
Naked RNA
| CPR
Picorna
Calici
Reo
57
Major antigens of influenza
Hemagglutinin
| Neuroaminidase
58
MCC of RT infections
Influenza
59
Degrades protective layer of mucus in RT found in influenza
| Cleaves sialic acid to release virus progeny
Neuraminidase
60
Initiates infection of cell by influenza
| Neutralized by antibody
Hemagglutinin
61
Antigenic shifts causing pandemics
Influenza A
62
Epidemics due to antigenic drifts
Influenza B
63
DOC for influenza
Oseltamivir
| Zanamivir
64
DOC for influenza A
Amantadine
| Rimantidine
65
Paramyxoviruses
| Envelope spikes
Parainfluenza
RSV
Measles
Mumps
66
Warthin finkleday bodies
Rubeola
67
SOD of mumps
Parotitis
Orchitis
Meningitis
68
Most Impt cause of pneumonia and bronchiolitus in infants
RSV
69
Ttt for RSV
Ribavirin
70
Causes croup with steeple sign
| Inspiratory stridor
Parainfluenza 1 and 2
71
Ttt for croup
Racemic epinephrine
72
Bullet shaped enveloped virus
Rabies virus
73
Cause of early death in rabies
Early brainstem encephalitis
74
Virus with club shaped spikes
Coronavirus
75
Reservoir horseshoe bat
| Intermediate host civet cat
Corona virus
76
Atypical pneumonia progressing to ARDS
SARS
77
In SARS, coronavirus attaches to what receptor
Ace 2 receptor
78
Non cavitary ground glass infiltrates
Sars
79
Breakbone fever
Dengue virus (flaviviridae)
80
Most prevalent blood borne antigen
Hepatitis C (flavivirus)
81
Dx test for hepa C
Anti HVC
| HVC Rna
82
With liver specific microRNA
Hepatitis C
83
Hepatitis with highest chronic carrier rate
Hepatitis C
84
Main cause of essential mixed cryoglobulinemia
Hepatitis C
85
MC indication for liver transplantation
Hepatitis C
86
3 day rash with post LAD
Rubella (togaviridae)
87
Immune complex polyarthritis in adults
Rubella (togaviridae)
88
Congenital rubella syndrome assoc abnormalities
```
PDA
Blueberry muffin rash
Sensorineural hearing loss
Cataracts
MR
```
89
Converts single strand RNA to double strand dna
Reverse transcriptase
90
Major capsid protein in HIV
Serologic marker
Located in core
P24
91
HIV fusion protein with host cell
Gp41
92
HIV attachment protein interacts with CD4
| Rapid change in antigenicity
Gp120
93
Directs entry of DNA provirus to nucleus
| Essential for viral assembly
P17
94
Structural HIV genes
Gag
Pol
Env
95
Regulatory gene in HIV
| Activation of transcription of viral genes
Tat
96
Regulatory gene in HIV that decreases CD4 and class 1 MHC proteins
Nef
97
Phase of seroconversion in HIV
Phase 2
98
Cause of chronic diarrhea in aids
C. Parvum
99
Aids illnesses CD4
CMV retinitis
M. Avium pulmo dse
Histoplasmosis
100
Aids illnesses CD4
Disseminated Tb
HSV esophagitis
Esophageal candidiasis
Kaposi's sarcoma
101
Aids illnesses CD4
```
PCP pneumonia
Cerebral toxoplasmosis
Cryptococcus meningoenceph
Coccidiomycoses - c. Immitis
Chronic diarhhea - c. Parvum
```
102
For HIV prognostication
PCR
103
HAART
Two nucleoside inhibitors
Zidovudine lamivudine
Protease inhibitor
Indinavir
104
Retrovirus causing adult t cell leukemia and myelopathy
HTLV
105
Malignant t cells with flower shaped nucleus
HTLV
106
Thread like viruses
| Longest viruses
Ebola
107
Flavivirus
Bird mosquito man cycle
Neuroinvasive dse
West nile virus
108
MCC of epidemic encephalitis
Japanese B encephalitis
109
Jap B virus transmitted by
Culex spp
110
Jap B enceph on CT scan
Thalamuc infarcts
111
Only live vaccine given to AIDS
MMR
