Protozoa Flashcards
Produces cytopathic effect of E. Histolytica
Cysteine proteases
Mediates adherence of entamoeba
Lectin
Flask shaped colon ulcers
Dysentery without fever
Amebic colitis
Most common extraintestinal form of entamoeba
Anchovy sauce aspirate
Amebic liver abscess
Ttt for cyst carrier state of entamoeba
Diloxanide furoate
Luminal agents for entamoeba
Diloxanide furoate
Iodoquinol
Paromomycin
Falling leaf motility
Giardia lamblia
Variant surface protein
Giardia lamblia
Villous flattening, disruption of cytoskeleton Ultimately leads to enterocyte apoptosis
Giardia
Excessive flatus
Foul smelling diarrhea
Chronic: steatorrhea
Giardia
Acid fast parasite autoinfection in IS pts, self limited nonbloody diarrhea
Cryptosporidium parvum
Ttt for crytosporidium
Nitazoxanide
Infective and diagnostic stage of cryptosporidium
Thick walled oocysts
Pear shaped flagellated trophozoites
Trichimonas vaginalis
Greenish vaginal discharge
Trichomoniasis
Strawberry cervix
Ectocervicitis
Punctate hemorrhage
Trichomoniasis
Ttt for trichomoniasis
Metronidazole 2 g
Transmitted thru anopheles
Plasmodium
Infective stage of plasmodium
Sporozoites
Diagnostic stage of plasmodium
Trophozoites (ring forms)
Provides immunity to malaria
RBC defects
Banana shaped gametocyte
P. falciparum
Large round gametocyte
P. vivax
Recurrence of symptoms after temp abatement 2-4 weeks
Recrudescence
Falciparum, malariae
Return of disease after cessation, reactivation of hypnozoites (1-6 months)
Relapse
Vivax, ovale
Benign quartan
P. malariae
Malignant tertian
P. falciparum
Highest yield in blood samples for plasmodium
During fever or 2-3 hrs after peak
Punctate granulations in RBC
Schuffner - ovale, vivax
Coarse granulations in RBC
Maurer - falciparum
Fine granulations in RBC
Ziemann - malariae
Malarial or durck granulomas
Cerebral malaria
Intravascular hemolysis
Massive hemoglobinuria
ARF
Blackwater fever
P. falciparum
Septic shock due to plasmodium
Algid malaria
Endemic areas for plasmodium
Palawan
Kalinga apayao
Ifugao
Agusan del sur
Areas with Chloroquine resistant malaria
Palawan
Davao del norte
Compostela valley
Tissue schizonticide (liver) and gametocide (blood)
Primaquine
Blood schizonticide
Chloroquine
Quinine
Sporonticide in mosquito
Proguanil
Pyrimethamine
Ttt for Chloroquine resistant malariae
Mefloquine + doxycycline
Eradication of hypnozoites
Primaquine
Severe or pregnant
Chloroquine or quinine
Vivax and ovale ttt
Chloroquine + primaquine
Prophylaxis for plasmodium
Chloroquine
Prophylactic for areas with chloroquine resistance
Malarone
Mefloquine
Prophylaxis for MDR resistant falciparum
Doxycycline
Definitive host: domestic cat
Toxoplasma gondii
Preferred dx test for toxoplasmosis
IgM antibody
Intracranial calcifications
Congenital toxoplasmosis
Ttt for toxoplasmosis
Sulfadiazine + pyrimethamine
Transmitted by reduviid bug (triatoma)
Trypanosoma cruzi
Most often and severely affected tissue by t. Cruzi
Cardiac muscle
Periorbital edema in acute chagas dse
Romana’s sign
Ttt of chagas dse
Nifurtimox
Dx stage of t. Cruzi and t. Bruceii
Trypomastigotes in blood
Transmission by tsetse fly (glossina) bite
Trypanosoma brucei
Remarkable antigenic variation
Cyclical fever spike every 2 weeks
Trypanosoma bruceii
Enlargement of post cervical LN
Winterbottom’s sign
T. Bruceii
Hyperesthesia in t. Bruceii
Kerandel’s sign
Plasma cells with cytoplasmic immunoglobulin globules
Mott cells in t. Bruceii encephalitis
Ttt for t. Bruceii
Suramin
Melarsoprol
Transmission by bivalve molluscs and fish from red tide
Dinoflagellates
Granulomatous amebic encephalitis
Acanthamoeba castellani
Primary amebic meningoencephalitis
Naegleria fowleri
Only ciliated protozoan to cause human dse - dysentery
Round based wide neck intestinal ulcers
Balantidium coli
Transmitted by ixodes tick
Babesia microti
Transmitted by sandfly
Infective promastigotes
Leishmania spp
Ttt for leishmaniasis
Na stibogluconate (antimony)
Shellfish poisoning Paralytic Neurotoxic Diarrhetic Amnesic
Shellfish poisoning Paralytic: saxitoxin Neurotoxic: brevetoxin Diarrhetic: okadaic Amnesic: domoic
Dx stage entamoeba
Trophozoites
Mature & immature cysts