VIROLOGY Flashcards
A mature virus particle containing a nucleic acid core surrounded by a protein coat, with or without envelope is called a:
A. Nucleocapsid
B. Genome
C. Virion
D. Capsomer
C. Virion
Viruses are characterized by the presence of:
A. Mitochondrial DNA
B. DNA and RNA
C. Ribosomal RNA
D. RNA
B. DNA and RNA
What is the largest DNA virus?
A. Herpesvirus
B. Poxvirus
C. Adenovirus
D. Parvovirus
B. Poxvirus
Which of the following is the smallest RNA virus?
A. Paramyxovirus
B. Togavirus
C. Rhabdovirus
D. Enterovirus
D. Enterovirus
What is the first step in the replication cycle of a virus?
A. Attachment and penetration
B. Assembly of a virion
C. Release
D. Uncoating
A. Attachment and penetration
The virus capsid morphology is:
A. Square or round
B. Long or short
C. Ribbon-like or square
D. Helical or icosahedral
D. Helical or icosahedral
From what part of the virus is the envelope acquired?
A. Nuclear or cytoplasmic membrane
B. Nucleus or cytoplasm
C. Capsomeres or genomes
D. mRNA or DNA
A. Nuclear or cytoplasmic membrane
What is the site of virion assembly?
A. Capsomere
B. Nucleus or cytoplasm
C. Genomes
D. Membranes
B. Nucleus or cytoplasm
Which of the following is a DNA virus?
A. Retroviridae
B. Orthomyxoviridae
C. Herpesviridae
D. Paramyxoviridae
C. Herpesviridae
Which of the following is a RNA virus?
A. Pseudomyxoviridae
B. Papoviridae
C. Herpesviridae
D. Poxviridae
A. Pseudomyxoviridae
Specimens collected for virus isolation should be kept at:
A. 37 C
B. 20 C
C. 4 C
D. -20 C
C. 4 C
At what temperature should clinical specimens suspected of containing viruses kept for transport that takes days?
A. -70 C
B. 37 C
C. 4 C
D. -10 C
A. -70 C
In what family of viruses, after primary infection, does an individual become latently infected and then the infection can be reactivated?
A. Adenoviridae
B. Herpesviridae
C. Poxviridae
D. Papovaviridae
B. Herpesviridae
Cytomegalovirus isolation is best accomplished using:
A. Monkey kidney cells
B. A549 cells
C. Human embryonic fibroblasts
D. Embryonated hen’s eggs
C. Human embryonic fibroblasts
Which of the following viruses causes acute central nervous system disease in humans and animals?
A. Rabies
B. Influenza
C. Mumps
D. Measles
A. Rabies
What specimen/s should be collected from a patient with suspected enteroviral meningitis?
A. Stool
B. Throat swab
C. Cerebrospinal fluid
D. AOTA
D. AOTA
Influenza A viruses can be detected in cell cultures by:
A. Complement-fixation test
B. Hemadsorption assay
C. Immunoperoxidase test
D. Hemagglutination-inhibition test
B. Hemadsorption assay
The best host systems for influenza virus isolation are:
A. Monkey kidney cells and embryonated hen’s eggs
B. Monkey kidney cells and human embryonic fibroblasts
C. Human embryonic fibroblasts and embryonated hen’s eggs
D. Monkey kidney cells and A549 cells
A. Monkey kidney cells and embryonated hen’s eggs
What common antigen is cross-reactive in all human adenoviruses?
A. Fiber
B. Hexon
C. Hemagglutinin
D. Capsomere
B. Hexon
The following characteristics are similar in both influenza and parainfluenza viruses, except:
A. Helical symmetry
B. Lipid envelope
C. Budding from cytoplasmic membrane
D. Segmented RNA genome
D. Segmented RNA genome
Myxoviridae virus envelope contains both:
A. Neuraminidase and hemagglutinin
B. Lipoprotein and nonsegmented nucleocapsid
C. Lipid and double stranded DNA
D. Hemagglutinin and nonsegmented nucleocapsid
A. Neuraminidase and hemagglutinin
Eosinophilic cytoplasmic inclusions are elementary bodies of the:
A. Herpesvirus
B. Poxvirus
C. Poliovirus
D. Papilloma virus
B. Poxvirus
German measles is caused by:
A. Rubeola virus
B. Rubella virus
C. Varicella-zoster virus
D. Vaccinia virus
B. Rubella virus
What is an alastrim infection?
A. Smallpox
B. Chickenpox
C. Mild form of smallpox
D. Measles
C. Mild form of smallpox
Which of the following laboratory procedures is routinely used for the detection of hepatitis B virus (HBV) in blood donors?
A. Solid-phase RIA
B. ELISA
C. Culture
D. A and B
D. A and B
Which of the following laboratory procedures is the most rapid method for diagnosis of a virus infection?
A. Culture
B. Serological tests
C. Direct electron microscopy
D. Cytopathic effect (CPE) in cell cultures
C. Direct electron microscopy
What specimen/s should be collected from a patient with suspected influenza?
A. Stool
B. Throat swab
C. Urine
D. AOTA
B. Throat swab
What virus group contains a double-stranded, segmented RNA genome?
A. Herpesvirus
B. Influenza virus
C. Parainfluenza virus
D. Reovirus
D. Reovirus
Enteroviruses can be differentiated from rhinoviruses by:
A. Acid resistance
B. Size determination
C. Ether stability
D. Ribonuclease treatment
A. Acid resistance
What virus is the most frequent cause of gastroenteritis in children during the winter months?
A. Influenza viruses
B. Adenoviruses
C. Rotavirus
D. Hepatitis A virus
C. Rotavirus
All of the following groups of viruses are resistant to ether treatment, except:
A. Herpesviruses
B. Adenoviruses
C. Enteroviruses
D. Reoviruses
A. Herpesviruses
The most common method for rapid electron microscopy examination is:
A. Negative staining
B. Acid-fast staining
C. Gram stain
D. Periodic Acid-Schiff stain
A. Negative staining
Various virus groups can be differentiated in negatively stained specimens by their:
A. Envelope
B. Cytoplasmic membrane
C. Morphology
D. Nucleus
C. Morphology
