Viral skin infections Flashcards

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1
Q

Chickenpox is caused by which virus

A

Varicella zoster virus- varicella is the chickenpox part, shingles in the zoster part.

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2
Q

Features of chickenpox

A

Primary infection mainly in childhood
Generalised rash and fever
Virus establishes latency

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3
Q

Features of shingles

A
Reactivation of the chicken pox virus. 
Dermatomal distribution (can even effect just half the face)
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4
Q

Symptoms/ process of chickenpox

A
Macules to papules to vesicles to scabs to recovery
This goes along with
Itch
Fever
Inflamed skin
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5
Q

Symptoms of shingles

A
Dermatomal distribution
Reactivation of Varicella Zoster virus
Starts with tingling pain, then erythema, then vesicles to crusts. 
Pain increases as age increases 
Scarring is uncommon
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6
Q

Who is likely to get shingles

A

Elderly people

Immunocompromised people

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7
Q

Neonatal varicella zoster virus

A

Occurs in neonates when mother develops chickenpox in late pregnancy.

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8
Q

How is neonatal VZV prevented?

A

Varicella zoster immune globulin in susceptible women.

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9
Q

Opthalmic zoster

A

Shingles in the opthalmic region of the trigeminal nerve.

Shingles present on part of the face. NEEDS URGENT REFERRAL

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10
Q

Ramsay Hunt syndrome

A

Complication of shingles when it affects the facial nerve.
Vesicles and pain in the auditory canal (ear) and throat.
Facial palsy (7th nerve)
Also irritation of the 8th cranial nerve- deafness, vertigo, tinnitus (ringing or buzzing in the ear)

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11
Q

What else is Ramsay Hunt syndrome known as?

A

Optic herpes zoster or geniculate.

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12
Q

Vaccination for chickenpox

A

Live attenuated vaccine- used as routine around the world, not in UK. Used for susceptible healthcare workers.

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13
Q

Vaccine for shingles

A

Same vaccine as chickenpox however higher titre.

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14
Q

Herpes simplex virus

A

Two types- I or II

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15
Q

Symptoms of herpes simplex virus

A

gingivostomatitis- inflammation of the oral mucosa and gingivae.
Extensive ulceration in and around the mouth.
Duration of about a week.

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16
Q

Who contracts herpes simplex virus?

A

Pre-school children

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17
Q

Recurrence of herpes simplex virus

A

Causes blistering rash at vermillion border (top border of lips)
can also spread e.g. into eczema herpeticum

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18
Q

Type I herpes simplex virus features

A

Oral lesions common
Causes half of genital herpes
Causes encaphilitis

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19
Q

Type II herpes simplex virus features

A

Oral lesions uncommon
Causes half of genital herpes
Causes encaphilitis

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20
Q

Therapy for herpes simplex virus

A

Aciclovir- analogue of guanosine. Replaces it in viral DNA disallowing DNA replication. Effective and non toxic antiviral however does not eliminate latent viral DNA

21
Q

Labs for herpes simplex virus

A

Swab- antiviral medium

Antibody testing.

22
Q

Erythema multiforme

A

Side effect of some drugs and certain infections. E.g. herpes simplex, mycoplasma pneumoniae.

23
Q

Molloscum contagiosum

A

Freshly, firm, umbilicated pearlescent nodules.
Self limiting however can be removed by local application of liquid nitrogen
Common in children and can be sexually transmitted.

24
Q

Warts are caused by

A

The human papilloma virus

25
Q

Features of warts

A

Commonest in children.
Self limiting- however use topical salicylic cream
Called verrucas when they are on the feet.

26
Q

What other issues (other than warts) can the human papilloma virus cause

A

Genital warts- HPV type 11 and 6

Cervical cancer- HPV type 16 and 18

27
Q

Treatment of HPV

A

Gardasil vaccine treats types 11 and 6 (genital warts)

Cervarix treats types 16 and 18

28
Q

Herpangina

A

blistering rash of the back of the mouth.
Caused by enterovirus- coxsackie virus and echovirus
Self limiting
Swab the lesion and send a stool sample for PCR for enterovirus.

29
Q

Hand foot and mouth disease

A

Typically in children
Family outbreaks
Enteroviruses (especially coxsackie)

30
Q

What causes erythema infectiosum

A

Parvovirus B19

31
Q

What other names are there for erythema infectiosum?

A

Slapped cheek disease

32
Q

Presentation of erythema infectiosum

A

Rash on face

When this fades you get a lacy macular rash on the body.

33
Q

Presentation of erythema infectiosum in adults

A

The rash may be absent- but acute polyarthritis may be more common (especially in the wrists)

34
Q

Complications of parovirus B19

A

Spontaneous abortion
Aplastic crices- sudden drop in haemoglobin. Seen in patients with short red cell lifespan
Chronic anaemia in immunosuppressed patients.

35
Q

How to diagnose parovirus B19?

A

Antibody test- parovirus B19 IgM test.

36
Q

Orf

A

Virus of sheep “scabby mouth”

37
Q

Presentation of orf

A

Firm fleshy nodule on hands of farmers

38
Q

Treatment of orf

A

Self limiting

39
Q

Cause of syphilis

A

Sexually transmitted infection with bacterium Trepanema pallidum

40
Q

Presentation of syphilis

A

Primary infection- painless ulcers at site of entry (chancre)
Secondary infection- red rash over body. Prominent on the soles of the feet. Mucous membranes “snail track” ulcers.
Tertiary infection- CNS, cardiovascular, gummatous

41
Q

Treatment of syphilis

A

Injection of penicillin

42
Q

Diagnosis of syphilis

A

Blood test or swab of chancre for PCR.

43
Q

Cause of lyme disease

A

ticks carry the bacterial infection Borrelia burgdorferi

44
Q

Presentation of lyme disease

A

Early- erythema migrans- rash in halo shape
LAte- heart block
Nerve palsies
Arthritis

45
Q

Treatment of lyme disease

A

Doxycycline or amoxicillin

46
Q

Labs for lyme disease

A

Blood test for antibody for organism

47
Q

Presentation of zika

A

Mild fever, rash, headaches, arthralgia, myalgia

Presentation similar to dengue and chickenunya infections.

48
Q

How is zika spread?

A

mosquitoes and sexual transmission

49
Q

Characteristics of zika virus

A

Only 1/5 of people with the virus become ill.

Onset of symptoms- 3-12 days. Resolves in 2-7 days after onset.