Viral Pathogenesis of GI Disorders Flashcards
1
Q
What is Virulence?
A
- The capacity of the virus to cause a disease
- severity of disease
2
Q
M cells
A
- Carrier of secretory IgA
- “Achilles’ Heel of gut”
3
Q
What viruses consist of Genus Enteroviruses
A
+ ssRNA viruses which are:
- Poliovirus
- Cocksackievirus
- Echovirus
- Enterovirus
4
Q
What are the viruses of Diarrhea?
A
- Rotovirus
- Calcivirus (Norwalk)
- Astrovirus
- Some Adenoviruses
5
Q
What are Enteroviruses?
A
- Replicate in intestines
- Resistant to acid (pH 3), alcohol, phenolics, and detergents
- Transmission: Fecal-oral
- Symptoms: meningitis, hand-foot-mouth disease, and pleurodynia
6
Q
Echoviruses
A
- Infantile diarrhea
- Transmission: fecal-oral
7
Q
Rotavirus
A
- Most common cause of infantile gastroenteritis
- Infects duodenum and proximal jejunum
- Transmission: fecal-oral
- Symptoms: vomiting, fever, watery diarrhea
- Reoviridae
- Spoked-wheel appearance
8
Q
Calcivirus (Norwalk virus)
A
- Diarrhea in older children and adults
- Transmission: fecal-oral
- Symptoms: Headache, abdominal pain, fever, 1-5 days of diarrhea
- Calciviridae
9
Q
Adenovirus
A
double-stranded DNA virus
10
Q
Astrovirus
A
single-stranded RNA virus: star-like pattern
11
Q
Coronavirus
A
single-stranded RNA virus
