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Med Micro Exam 3 > Viral Hepatitis > Flashcards

Viral Hepatitis Flashcards

1
Q

What is Hepatitis A virus’ family and genus? How many serotypes?

A
  • Family: Picornaviridae
  • Genus: Hepatovirus
  • 1 serotype
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2
Q

How is Hepatitis A transmitted? How long do symptoms last?

A
  • Fecal-oral contamination of food/water (primarily)
  • Person-to-person contact
  • Blood-borne
  • Symptoms last: 1-2 weeks
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3
Q

What is the Serological course of Hepatitis A virus? Incubation period?

A
  • Replicates in liver, excreted in bile, shed in stool

- Incubation period: 15-49 days (avg. 25 days)

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4
Q

What is the age for asymptomatic (anicteric) Hepatitis A?

Symptomatic?

A

Asymptomatic: under 6 years old = >90%
Symptomatic: over 14 yeas old = 70-80%

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5
Q

What are Hepatitis A’s risk factors?

A
  • Men having sex with men
  • drug users
  • chronic liver disease
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6
Q

What are diagnostic tests for Hepatitis A? Immunity?

A
  • Diagnostic test: IgM anti-HAV via stool

- Immunity: IgG anti-HAV

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7
Q

What is Hepatitis E virus’ family? How many serotypes?

A
  • Family: Calciviridae

- 1 serotype

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8
Q

How is Hepatitis E transmitted?

A
  • Fecal-oral contamination of food/water (primarily)

- Swine = main reservoir in north america

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9
Q

What is the serological course of Hepatitis E virus? Incubation period?

A
  • liver enzymes elevate after 4-5 weeks of oral ingestion and remained elevated for 20-90 days
  • Incubation period: 15-60 days
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10
Q

Who is most at risk for Hepatitis E virus?

A

-Pregnant women

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11
Q

What is Hepatitis C’s family and genus? How many Genotypes?

A
  • Family: Flaviviridae
  • Genus: Hepacivirus
  • 6 genotypes
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12
Q

How is Hepatitis C transmitted?

A
  • Transfusion
  • Mother to Infant
  • heterosexual partner (1 in 1,000 per year); accounts for 15-20% of acute and chronic infections
  • needlestick injury
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13
Q

How to diagnose Hepatitis C?

A
  • hepatitis C antibody tests
  • Qualitative HCV RNA test (PCR test)
  • Quantitative HCV RNA test
  • genotyping
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14
Q

What is Hepatitis B virus’ family? How many Genotypes?

A
  • Family: Hepadnaviridae

- Genotypes: 6 genotypes (A-F)

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15
Q

How is HBV replicated?

A
  • Involves reverse transcription
  • part in nucleus, part in cytoplasm
  • nucleus converted to circular DNA
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16
Q

What are the different types of HBV antigens?

A
  • HBsAg: surface antigen
  • HBcAg: core antigen
  • HBeAg: soluble antigen; portion of HBcAg
17
Q

What are the different types of HBV antibodies?

A
  • anti-HBs: protective antibody
  • anti-HBe: process of recovery
  • anti-HBc: indicates past exposure
18
Q

How is HBV transmitted? Risk factors?

A
  • exposure to blood or body fluids
  • Risk factors: injection drug use and transfusion
  • Neonates = high risk of chronic infection

Med Micro Exam 3 (9 decks)

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