Viral Pathogenesis

Question 1

Explain the effects of tissue tropism, virulence and host responses on the nature of viral disease.

Answer 1

Tropism- a virus of a given nature is likely to infect a certain tissue type

Question 2

Compare and contrast acute local disease versus acute systemic disease in incubation periods, virus shedding and transmission, host responses, and likelihood of re-infection.

Answer 2

Acute local- quickly resolved, short lived immunity, no viremia, IgA mediated

Acute systemic- lifelong immunity, longer incubation, IgG mediated

Question 3

Detail two differences between persistent and latent infection.

Answer 3

Persistent- a virus that continues to produce new virus over a long period of time

Latent- Refers to virus infection in which the virus genome is relatvely silent, with little to no disease manifestation

Question 4

List the potential outcomes and types of virus diseases, with the contributing factors.

Answer 4

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