Viral Oncogenes Flashcards
What virus family is Hepatitis B virus part of and what human tumor does it cause?
Hepadnavirus family
Hepatocellar carcinoma (HCC)
Cofactors include aflatoxin, alcohol, smoking
What virus family is Epstein-Barr virus (EBV) part of and what human tumors does it cause?
Herpesvirus family
Burkitt’s lymphoma (cofactor malaria)
EBV- associated malignancies (cofactor immunodeficiency)
nasopharyngeal carcinoma (cofactor nitrosamines, genetic)
Hodgkin’s lymphoma
gastric carcinoma
What virus family is KSHV (HSV8) part of and what human tumors does it cause?
Herpesvirus
Kaposi sarcoma (cofactor AIDS)
Castleman’s disease
primary effusion lymphomas
What virus family is Hepatitis C virus part of and what human tumor does it cause?
Flavivirus
Hepatocellular carcinoma (cofactor aflatoxin)
What virus family is HPV16, 18, 31, 33, 35, 39 and other part of and what human tumor does it cause?
Papillomaviruses
Anogenital cancers, some upper airway cancers (cofactor smoking, oral contraceptives)
What virus family is HPV5, 8, 17, 20, 47 part of and what human tumor does it cause?
Polyomavirus
Skin cancer (cofactor UV, immunosuppression)
What virus family is MCV part of and what human tumor does it cause?
Polyomavirus
Markel cell cancer
What virus family is BK part of and what human tumor does it cause?
Polyomavirus
Prostate preneoplastic lesions
What virus family is JC part of and what human tumor does it cause?
Polyomavirus
Brain tumors
What virus family is SV40 part of and what human tumor does it cause?
Polyomavirus
Mesothelioma, brain tumors, etc.
What virus family is HTLV-1 part of and what human tumor does it cause?
Retroviruses
ATL
What virus family is HTLV-2 part of and what human tumor does it cause?
None not associated with human malignancy
