Oncogene Examples

Question 1

What type of cancer does K-ras cause?

What is the nature of protein?

Answer 1

Lung, ovarian, colorectal, bladder, carcinomas (5-20%)

Small G protein

Question 2

What type of cancer does N-ras cause?

What is the nature of protein?

Answer 2

Head and neck cancers (30%)

Small G protein

Question 3

What type of cancer does H-ras cause?

What is the nature of protein?

Answer 3

Colorectal carcinomas (30%)

Small G protein

Question 4

What type of cancer does c-myc cause?

What is the nature of protein?

Answer 4

Various leukemia’s, carcinomas (10-50%)

TF

Question 5

What type of cancer does L-myc cause?

What is the nature of protein?

Answer 5

Lung carcinomas (10%)

TF

Question 6

What type of cancer does N-myc-DDX1 cause?

What is the nature of protein?

Answer 6

Neuroblastomas, lung carcinomas (30%)

TF

Question 7

What type of cancer does cyclin D1-exp1-hst1-ems1?

What is the nature of protein?

Answer 7

Breast and squamous cell carcinomas

G1 cyclin

Question 8

What type of cancer does cdk4-mdm2-sas-gli cause?

What is the nature of protein?

Answer 8

Sarcomas (10-30%)
HNSCC (40%)
B-cell lymphomas (25%)

CDK, p53, antagonist

Question 9

What type of cancer does Cyclin E cause?

What is the nature of protein?

Answer 9

Gastric cancers (15%)

Cyclin

Question 10

What type of cancer does cdk6 cause?

What is the nature of protein?

Answer 10

Gliomas (5%)

CDK