Viral Hepatitis Pharmacology Flashcards
If a patient has chronic hepatitis B, what 6 drugs could you use for treatment?
entecavir, lamivudine, telbivudine, peg-interferon alpha 2 a, tenofovir, adefovir
what is a major reaction caused by tenofovir?
new onset or worsening renal impairment
what is a major reaction caused by adefovir?
nephrotoxicity
what is the most common adverse reaction associated with adefovir?
asthenia and increased creatinine
what are the precautions for lamivudine?
for co-infected HIV-1/ HBV patients: emergence of lamivudine resistant HBV variants; pancreatitis
what is the contraindication for telbivudine?
combination of telbivudine with PEG interferon alpha-2a because there is increased risk of peripheral neuropathy
what are the contraindications for PEG interferon alpha 2a?
autoimmune hepatitis, hepatic decompensation in patients with cirrhosis, and use in neonates/infant
which treatment for HBV does not have a BB warning associated with it?
Adefovir
what is the only HBV treatment for ages 2-12?
entecavir
what is the black box warning associated with peg interferon alpha 2-b?
it can cause aggravate fatal or life-threatening neuropsychiatric, autoimmune, ischemic, and infectious disorders
what are the adverse reactions associated with peg-interferon 2 alpha b?
flu like symptoms
what is the MOA of elbasvir?
it is a NS5A inhibitor
what is the MOA of grazoprevir?
NS3/4A protease inhibitor
what is the MOA of ledipasvir?
NS5A inhibitor
what is the MOA of sofosbuvir?
nucleotide analog NS5B polymerase inhibitor
