Viral Hepatitis Pharmacology Flashcards
If a patient has chronic hepatitis B, what 6 drugs could you use for treatment?
entecavir, lamivudine, telbivudine, peg-interferon alpha 2 a, tenofovir, adefovir
what is a major reaction caused by tenofovir?
new onset or worsening renal impairment
what is a major reaction caused by adefovir?
nephrotoxicity
what is the most common adverse reaction associated with adefovir?
asthenia and increased creatinine
what are the precautions for lamivudine?
for co-infected HIV-1/ HBV patients: emergence of lamivudine resistant HBV variants; pancreatitis
what is the contraindication for telbivudine?
combination of telbivudine with PEG interferon alpha-2a because there is increased risk of peripheral neuropathy
what are the contraindications for PEG interferon alpha 2a?
autoimmune hepatitis, hepatic decompensation in patients with cirrhosis, and use in neonates/infant
which treatment for HBV does not have a BB warning associated with it?
Adefovir
what is the only HBV treatment for ages 2-12?
entecavir
what is the black box warning associated with peg interferon alpha 2-b?
it can cause aggravate fatal or life-threatening neuropsychiatric, autoimmune, ischemic, and infectious disorders
what are the adverse reactions associated with peg-interferon 2 alpha b?
flu like symptoms
what is the MOA of elbasvir?
it is a NS5A inhibitor
what is the MOA of grazoprevir?
NS3/4A protease inhibitor
what is the MOA of ledipasvir?
NS5A inhibitor
what is the MOA of sofosbuvir?
nucleotide analog NS5B polymerase inhibitor
what is the MOA of velpatasvir?
an HCV Ns5A inhibitor
when do you use Boceprevir?
with peginterferon alfa and ribavirin
