Pathology of the GI Tract- Liver and Gallbladder (3) Flashcards
what is the most common morphologic pattern of drug or toxin induced liver injury?
necrosis of perivenular hepatocytes (zone 3) is the typical feature of drug-induced liver injury
what is the most common culprit for idiosyncratic reactions, which are the most common form of drug-induced liver injury ?
antimicrobial drugs
what are the three forms of alcohol related liver disease?
steatosis, steatohepatitis, and steatofibrosis/cirrhosis
how does steatosis present?
hepatomegaly with minimal symptoms, mildly elevated bilirubin and alk phos
how does steatohepatitis present?
tender hepatomegaly, +/- cholestasis, hyperbilirubinemia, AST:ALT 2:1 levels, elevated alk phos
how does steatofibrosis/cirrhosis present?
labs reveal hepatic dysfunction if enough liver tissue left, hypoproteinemia, coag abnormalities
what is NAFLD strongly associated with?
insulin resistance
what is a patient with NASH at risk for developing?
NASH cirrhosis or HCC
where does fibrosis of the liver typically develop?
around the central vein
how does pediatric NAFLD differ from adult NAFLD?
typically children show more diffuse steatosis and portal (rather than central) fibrosis, and ballooned hepatocytes may not be present
how does NAFLD present?
it is typically asymptomatic except for signs and symptoms of metabolic syndrome
what is hemochromatosis caused by?
excessive iron absorption
what is occurring in hereditary hemochromatosis?
regulation of intestinal absorption of dietary iron is abnormal
what is the main regulator of iron absorption?
hepcidin
what gene encodes for hepcidin?
HAMP gene