Viral Hepatitis Flashcards
What is the definition of hepatitis?
Inflammation of the liver parenchymal tissue and hepatocytes
What are the components of the portal triad?
Artery, vein and bile
Where are zone three hepatocytes?
Right next to the central vein
What are the general histological characteristics of hepatitis?
Collagenous deposits surrounding hepatocytes
Why do we care if patients have hepatitis w/o symptoms?
Chronic inflammation can lead to cirrhosis and HCC
What are the ssx of hepatitis?
Malaise N/v HA Myalgias Abdo pain
What is fulminant hepatitis?
Condition where there is so much inflammation in the liver, that it fails
What are the three main immune related caused of hepatitis?
Autoimmune
Primary biliary cirrhosis
Primary sclerosing cholangitis
What are the three hereditary causes of hepatitis?
Wilsons
Hemochromatosis
A1ATD
Which hepatitis viruses are self limited diseases?
A and E
Which hepatitis strains can cause chronic disease?
BCD
What are the abs that are found in autoimmune hepatitis?
ANA
ASM
LKM
What is the treatment for autoimmune hepatitis?
Steroids or immunomodulators
What are LFTs like in autoimmune hepatitis?
Increased ALT/AST
In which gender more commonly has autoimmune causes of hepatitis?
Women
What is the classic histological characteristic of autoimmune hepatitis?
Portal triad inflammation
What are the ssx of autoimmune hepatitis?
Asymptomatic, until cirrhosis overwhelms the liver
What is primary biliary cirrhosis? Which antibody is elevated in this disease?
Immune mediated destruction of the bile canaliculi
AMA (80% sensitive)
What happens to cholesterol in primary biliary cirrhosis?
Increases
Which disease has an increased chance of developing with primary biliary cirrhosis?
Osteoporosis
What is the treatment for primary biliary cirrhosis?
Urso (bile acid supplement)
What is primary sclerosing cholangitis? What is the antibody that is elevated in this disease?
Immune mediated stricturing of the biliary tree (macroscopically), that can involve intra and extrahepatic duct systems
ANCA+
What IBD is associated with primary sclerosing cholangitis?
UC
What is the treatment for primary sclerosing cholangitis?
None
How fast does primary sclerosing cholangitis progress?
decades
What are the viral infections of the liver besides classic hepatitis viruses? (6)
CMV Herpes EBV Yellow fever Adenovirus HIV
What are the parasitic infections that can cause hepatitis?
Toxoplasmosis
Leptospirosis
Q fever
Rocky mountain spotted fever
What is the cause of Q fever?
Coxiella burnetii
What two abx can cause hepatitis?
Amox
Nitrofurantoin (macrobid)
What antiarrhythmic can cause hepatitis?
Amiodarone