Liver Pathology III Flashcards
True or false: many of the drug induced liver diseases mimic other liver clinical diseases
True
What is phase I part of drug metabolism?
Oxidation
Reduction
Hydrolysis
What is phase II parts of liver metabolism?
Glucuronidation
and others
What zone of the liver is susceptible to toxic metabolites? WHy?
Zone 3
has lowest oxygen content
What type of drugs produce specific, predictable lesions of the liver?
Intrinsic
What type of drugs cause unpredictable lesions in the liver, and hypersensitivity reactions?
Idiosyncratic
Macrovesicular fatty change occurs with what type of liver insult? Microvesicular?
Maco = EtOH Micro = tetracyclines, salicylates,
What is the effect of acetaminophen on the liver?
Necrosis
What is the effect of tetracycline on the liver?
Microsteatosis
What is the effect of methotrexate on the liver?
Macrosteatosis
What is the effect of halothane on the liver?
Hepatitis
What is the effect of isoniazid on the liver?
Hepatitis
What is the effect of amiodarone on the liver?
Fibrosis
What is the effect of steroids on the liver?
Cholestasis
What is the effect of erythromycin on the liver?
Cholestasis
Porto-central bridging necrosis happens with what drug?
Halothane
Pathologic changes in the liver are seen with what level of daily EtOH consumption in men? Women?
Men >80g/day
Women >40g/day
What is the initial liver change with EtOH consumption? Is this reversible?
Steatosis
Reversible
What is the intermediate liver change with EtOH consumption? Is this reversible?
hepatitis
Reversible
What is the chronic liver change with EtOH consumption? Is this reversible?
Cirrhosis
Not reversible
What type of inflammation occurs with acute hepatitis? Chronic?
Acute = PMN infiltration, mild fibrosis Chronic = hyaline change + severe fibrosis
Where in the liver does most of the fat accumulate?
Pericentral (centrilobular) zone