Path of small intestines Flashcards
What is the clinical course of gastric carcinoma?
Asymptomatic until late
What is the prognosis of gastric carcinoma? Why?
Depends on depth, and mets, but usually found late d/t lack of symptoms until late
What are the three nodes that usually have mets from gastric carcinomas?
Virchow nodes
Sister Mary Joseph nodule
Krukenbery tumors
What a the sister mary joseph nodule?
mets around the umbilicus (reddening
What are Krukenberg tumors?
Mets to the ovaries from gastric carcinomas
What are the usually histologically characteristics of Krukenburg tumors?
Signet rings that are PAS positive (from diffuse type)
What lymphomas are associated with gastric tumors? Why?
B cell lymphoma (MALTomas) d/t B cell proliferation in response to H.Pylori infection
What are the B cell markers?
CD19 CD20, CD21
What are carcinoid tumors?
Neuroendocrine tumors from gastric cells that can secrete 5HT and bradykinin
What are the histological characteristics of gastric lymphomas?
Lymphoid cells infiltrate through glands and walls (uniform B cell)
What is the cause of GIST? (genetic, cell type)
Cells of Cajal get a c-KIT oncogene
What is the treatment for GIST?
Imatinib
What is the major prognostic factor for GIST?
Size
What cells are constantly proliferating in the GI Tract?
Basal cells
What is idiopathic IBD?
Chronic, relapsing inflammatory disorders of the intestinal tract of obscure origin
What are the two types of IBD?
Crohn’s disease
Ulcerative colitis
What is the supposed cause of IBD?
Unregulated and exaggerated immune response to normal gut flora
Which has extraintestinal inflammatory manifestations: Crohn’s or Ulcerative colitis?
Both
Which has epithelial changes that can lead to carcinoma: crohn’s disease or Ulcerative colitis
Both
How do you diagnose IBD?
H&P
x-ray
histology
What is the antibody that is associated with Crohn’s? UC?
UC = ANCA Crohn's = anti-saccharomyces
What cell has an abnormal response in IBD?
T cells
What do Th2 cells drive?
Humoral response
What type of hypersensitivity reaction is suspected in IBD?
delayed type hypersensitivity
What is Crohn’s disease? Where in the GI tract can this occur?
Trans-mural chronic ulceration IBD characterized by bowel inflammation, non-caseous granulomas,
Can occur anywhere in the GI tract
What is the most affected region in Crohn’s disease?
terminal ileum
Who usually gets Crohn’s disease?
Female Jews who smoke
What are the ssx of Crohn’s disease?
Diarrhea, fever, pain.
What is the major complication of Crohn’s disease?
Transmural fistula development
What are the malabsorption problems that can occur with Crohn’s disease?
Steatorrhea
Pernicious anemia
Which has a stronger predisposition to develop into cancer: UC or Crohn’s disease?
UC
What are skip lesions? What disease is it seen in?
a wound or inflammation that is clearly patchy, “skipping” areas that thereby are unharmed. It is a typical form of intestinal damage in Crohn’s disease
What disease has early aphthoid ulcers?
Crohn’s disease
Cobblestone mucosa is characteristic of what disease?
Crohn’s disease
What is the string sign of Crohn’s disease?
Thickened luminal narrowing of the intestines seen in Crohn’s disease when using radiolabeled dye
What is the “creeping fat” found in Crohn’s disease?
Dull gray granular serosa that surround that entire intestines