Viral Hepatitis

Question 1

1. Hep A virus type
2. Tranismission route
3. Vaccine?
4. Complication
5. Hep screen feature

Answer 1

1. RNA
2. Faecal-to-oral
3. Yes
4. Cholestasis (Slowing of bile flow through the biliary system)
5. IgM Abs to Hep A

2. water or food
3. dark urine, pale stool, puritis, jaundice

Question 2

1. Hep B virus type
2. Transmission route
3. Vaccine?

Answer 2

1. dsDNA
2. Bodily fluid/blod OR Vertical trasnmission
3. Yes

IV drug users / tatto
Vertical transmission: mother to baby

Question 3

1. Hep C Virus type
2. Transmission route
3. Vaccine?
4. Complications

Answer 3

1. RNA
2. Blood OR bodily fluids
3. No
4. Liver cirrhosis/hepatocellular carcinoma

Question 4

5 viral markers

Hep B viral markers

Answer 4

1. HBsAg (in vaccine)
2. HBsAb (immune response)
3. HBcAb (IgM, IgG)
4. HBeAg (viral replication-high infectivity)
5. HBV DNA (direct count of the viral load)

IgM - active infection
High IgM - acute infection
Low IgM - chronic infection
IgG - past infection

Question 5

Viral Hepatitis Sx

Answer 5

Abdominal pain
Fatigue
Flu-like illness
Pruritus (itching)
Muscle and joint aches
Nausea and vomiting
Jaundice

Question 6

Viral Hepatitis LFT features

Answer 6

LFTs: Hepatic picture
High AST/ALT with less ALP
High bilirubin

AST/ALT released into serum by hepatocyte inflammation
>bilirubin: jaudice

Question 7

Hep B Mx

Answer 7

1st: Pegylated interferon
2nd: Tenovir/Entecavir

for viral suppression

Question 8

C for CURE

Hep C Mx

Answer 8

Direct-Acting Antivirals: Sofosbuvir

Question 9

Special D

1. Hep D virus type
2. Transmission route
3. Vaccine?

Answer 9

1. RNA
2. Only w/ Hep B
3. No

Rare in the UK

Question 10

1. Hep E virus type
2. Transmission route
3. Vaccine?

Answer 10

1. RNA
2. Faecal-to-oral
3. No

Rare in the UK