Viral hepatitis Flashcards
1
Q
chronic persistent hepatitis
A
- lymphocytic infiltration maintained within the portal triad
2
Q
chronic active hepatitis
A
- lymphocytic infiltration which spreads into the lobule
3
Q
treatment of HAV
A
- HAV vaccine + globulin within 2 weeks of exposure
- prophylaxis: HAV vaccine + globulin
4
Q
diagnosis of HAV
A
- HAV IgM
- HAV IgG: infection has cleared, confers immunity
5
Q
HBV DNA
A
- denotes viremia
- >10,000 denotes active disease
6
Q
treatment of chronic stable HBV
A
- entecavir is a new protease inhibitor with good results and little to no resistance
- pegylated interferon used for 4 months as a weekly injection has the highest percentage of seroconversion
7
Q
SE of adefovir
A
- occasionally can cause nephrotoxicity
8
Q
if pregnant woman is HBsAg positive
A
- child needs immune globulin and vaccine at birth
- C-section is not helpful
9
Q
goals of treatment
A
- conversion of HBeAg to HBeAb positivity
- loss of HBV DNA in blood
- long term conversion of HBsAg to HBsAb
- slow progression to cirrhosis or HCC
10
Q
surveillance program for HBV
A
- sonogram and a-fetoprotein q 6 months
11
Q
NIH definition of chronic HBV
A
- HBsAg positive for more than 6 months
- HBV DNA >105
- persistent or intermittent ALT/AST elevation
- liver biopsy showing chronic hepatitis
12
Q
NIH definition of inactive HBsAg carrier
A
- HBsAg positive for more than 6 months
- HBeAg negative, HBeAb positive
- persistently normal ALT/AST
- liver biopsy showing no inflammation
13
Q
NIH definition of resolved
A
- previously known history of hep B
- HBcAb positive or HBsAb positive
- undetectable HBV DNA
- normal ALT
14
Q
treatment of acute HDV
A
- supportive
15
Q
treatment of fulminant HDV
A
- liver transplant
