Antihelminths Flashcards
1
Q
overall MOA of benzimidazoles
A
- bind to free beta-tubulin and inhibiting the polymerization of tubulin and microtubule-dependent glucose uptake
2
Q
indications of albendazole
A
- neurocysticercosis caused by T. solium
- hydatid disease
3
Q
AE of albendazole
A
- dizziness
- vertigo
- increased ICP
- meningeal signs, seizures
4
Q
CI of albendazole
A
- pregnancy
5
Q
indications of mebendazole
A
- enterobius vermicularis
- trichuris trichiura
- ascaris lumbricoides
- hook worms
6
Q
AE of mebendazole
A
- angioedema, SJ syndrome when combined with metronidazole
7
Q
CI of mebendazole
A
- pregnancy: embyrotoxic and teratogenic
8
Q
indications of thiabendazole
A
- cutaneous larva migrans
- visceral larva migrans (toxocara canis)
- trichinosis
- drinking fruit juice aids in expulsion of worms
9
Q
AE of thiabendazole
A
- hepatoxicity and nephrotoxicity
- angioedema
- pruritus
- rash
- SJ syndrome
10
Q
MOA of ivermectin
A
- binds to glutamate-gated chloride channels in the nerve and muscle cell
- does not cross the BBB
11
Q
indications of ivermectin
A
- onchocerca volvulus
- strongyloidiasis
- onchocerciasis (river blindness)
12
Q
AE of ivermectin
A
- dizziness, encephalopathy, headache, hyperthermia, insomnia, seizure, somnolence, vertigo
- ALT/AST increased, bilirubin increased
- Mazzotti reaction - arthralgia, pruritus, rash, synovitus
13
Q
CI of ivermectin
A
- meningitis patients
- pregnancy
14
Q
MOA of diethylcarbamazine
A
- inhibit arachidonic acid metabolism in filarial mitochondria which enhances destruction by host
15
Q
indications of diethylcarbamazine
A
- lymphatic filariasis (Wucheria bancrofti)
- treatment most effect if given with albendazole
