Viral Chemotherapy -2 Flashcards
Chemotherapy
the treatment of infectious diseases by administration of drugs that are inhibitory or lethal to the infectious agents
selective toxicity
the drug must be harmful to the infectious agent without being harmful to the host
clinical use of antibiotics and other antibacterial compounds during viral infections is mostly to prevent
secondary bacterial infections
What are some other names for Acyclovir
- Acycloguanosine
- Zovirax
- Valtrex
What is Acyclovir
- a synthetic nucleoside analog of deoxyguanosine;
- its antiviral activity is restricted to herpesvirus
- requires 3 kinases to become active
What is another name for Amantadine
-symmetrel
what is Amantadine
a water soluble cyclic amine which specifically inhibits most strains of influenza A viruses by blocking viral uncoating
What is the target for Amantadine
M2 transmembrane channel
What is another name for Oseltamivir Phosphate
Tamiflu
What does Tamiflu do?
is acts as an inhibitor of the neuraminidase enzyme synthesized by influenze A and B viruses
What are other names for Zidovudine
- Azidothymidine
- AZT
- Retrovir
What is AZT
- first anti-HIV drug approved by the FDA
- inhibits viral reverse transcriptase as well as causing chain termination
- considered a maintenance drug
What are protease inhibitors
they inhibit viral proteases responsible for the cleavage of viral polyproteins into functional proteins by binding to their active sites
