Introduction to serology -2

Question 1

serology

Answer 1

the study of antigen-antibody interactions in vitro

Question 2

seroepidemiology

Answer 2

a population survey using a serologic test to screen for exposure and immunity to an infectious disease`

Question 3

the most practical method for collecting a serologic sample is

Answer 3

Vacutainer system

Question 4

red-top

Answer 4

tube used when serum is required

Question 5

lavender top

Answer 5

tube used when plasma is required

Question 6

serum

Answer 6

the fluid portion of blood remaining after the blood cells and materials responsible for clotting are removed

Question 7

normal serum

Answer 7

serum devoid of antibodies

Question 8

antiserum

Answer 8

serum containing antibodies

Question 9

hyperimmuneserum

Answer 9

serum containing high concentrations of antibodies

Question 10

plasma

Answer 10

this is the noncellular portion of blood

Question 11

agglutinin

Answer 11

antibody aggregates or clumps particulate antigen

Question 12

antiglobulin

Answer 12

antibody made against immunoglobulin, usually by injecting immunoglobulin into an animal of another species

Question 13

lysin

Answer 13

antibody that causes lysis of cell membrane

Question 14

neutralizing antibody

Answer 14

antibody that renders the microbe noninfectious

Question 15

preipitin

Answer 15

antibody that forms precipitates with soluble antigen

Question 16

seroconversion

Answer 16

the appearance of antibody in the blood in response to infection, disease, or immunization

Question 17

seronegative

Answer 17

animal with no detectable antigen-specific antibodies

Question 18

seropositive

Answer 18

animal with detectable antigen-specific antibodies

Question 19

serotype

Answer 19

the type of a microorganism as determined by its distinct antigenic properties

Question 20

subtype

Answer 20

variation within serotype

Question 21

serogroup

Answer 21

a group of bacteria containing a common antigen or a group of viral species that are closely related antigenically

Question 22

sensitivity

Answer 22

the minimum concentration of a substance that can be reliably by serological test
- measurement of false negative

Question 23

specificity

Answer 23

refers to its capacity to discriminate between ligands of similar structure by combining with them at different extents
-measurement of false positive

Question 24

titer

Answer 24

the reciprocal of the highest dilution (low concentration) of serum (antibody) that produces a test reaction