Introduction to serology -2 Flashcards
serology
the study of antigen-antibody interactions in vitro
seroepidemiology
a population survey using a serologic test to screen for exposure and immunity to an infectious disease`
the most practical method for collecting a serologic sample is
Vacutainer system
red-top
tube used when serum is required
lavender top
tube used when plasma is required
serum
the fluid portion of blood remaining after the blood cells and materials responsible for clotting are removed
normal serum
serum devoid of antibodies
antiserum
serum containing antibodies
hyperimmuneserum
serum containing high concentrations of antibodies
plasma
this is the noncellular portion of blood
agglutinin
antibody aggregates or clumps particulate antigen
antiglobulin
antibody made against immunoglobulin, usually by injecting immunoglobulin into an animal of another species
lysin
antibody that causes lysis of cell membrane
neutralizing antibody
antibody that renders the microbe noninfectious
preipitin
antibody that forms precipitates with soluble antigen
seroconversion
the appearance of antibody in the blood in response to infection, disease, or immunization
seronegative
animal with no detectable antigen-specific antibodies
seropositive
animal with detectable antigen-specific antibodies
serotype
the type of a microorganism as determined by its distinct antigenic properties
subtype
variation within serotype
serogroup
a group of bacteria containing a common antigen or a group of viral species that are closely related antigenically
sensitivity
the minimum concentration of a substance that can be reliably by serological test
- measurement of false negative
specificity
refers to its capacity to discriminate between ligands of similar structure by combining with them at different extents
-measurement of false positive
titer
the reciprocal of the highest dilution (low concentration) of serum (antibody) that produces a test reaction
