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Micro Exam 2 > Viral and Chlamydial- RTI > Flashcards

Viral and Chlamydial- RTI Flashcards

1
Q

ARD

A

Cold- benign, transitory, self limited

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2
Q

? ARD predominates

A

viral

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3
Q

viral causes of ARD

A

Rhino 25%, Corona 10%, Adeno and unknown 30-40 %

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4
Q

abx for ARD

A

not appropriate

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5
Q

Zicam

A

not to use since 2009

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6
Q

Rhino Epidemiology

A

hyperendemic in winter, more in children and young adults

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7
Q

transmission of ARD

A

aerosol, fomites, carriers , direct contact

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8
Q

major vector in person to person transmission of ARD

A

Hands

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9
Q

existence of human carrier state in ARD

A

highly probable

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10
Q

Rhino control

A

hand washing and disinfection

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11
Q

picovir

A

binds to virion canyon and halts infection

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12
Q

flu types

A

A (worst) , B, C : defined by nucleocaspid proteins

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13
Q

flu antigenic subtypes

A

large number of antigenic subtypes based on envelope proteins are known

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14
Q

flu: H hemagglutinin

A

viral attachment

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15
Q

flu: N neuraminidase

A

viral penetration and release from infected cells

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16
Q

flu manifestations

A

short incubation, abrupt onset, symptoms, 1 week, long convalescence

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17
Q

big worry for flu

A

complications

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18
Q

complications of flu

A

pulmonary, Reyes, Guillain-Barre

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19
Q

pulmonary complication of flu

A

primary viral pneumonia, secondary bacterial pneumonia

20
Q

secondary bacterial pneumonia causes

A

strep pnemo, staph aureus, H. flu B(HIB)

21
Q

Reyes syndrome

A

avoid aspirin in children

22
Q

Guillain-Barre syndrome

A

demylination, insult unclear (1976 swine flu vaccine) ~40% viral

23
Q

Dx of flu

A

clinical, direct viral isolation from throat (nasopharyngeal swabs), rapid test kits (reveals antigens)

24
Q

rapid test kits

A

false negative if early in course or low antigen

25
Q

flu tx

A

amantadine, timantadine, oseltamivir, zanamivir

26
Q

amantadine and rimantadine for flu type?

A

stops type A only

27
Q

amantadine and rimantadine MOA

A

stops uncoating/penetraring

28
Q

oseltamivir and zanamivir for flu type?

A

antagonizes both A and B

29
Q

oseltamivir and zanamivir MOA

A

neuraminadase inhibitor, stops spreading/release of virus

30
Q

major concern w/ flu tx

A

drug resistance

31
Q

flu vaccine formulated w/

A

the two most prevalent flu A viruses + the most prevalent type B virus

32
Q

recent flu vaccine changes

A

quadrivalent, high potency for elderly, recombinant and cell culture based, intradermal application

33
Q

quadrivalent

A

froms with 2 type A and 2 type B

34
Q

flu antigenic variation

A

shift and/or drift

35
Q

drift

A

point mutation of H or N proteins=minor

36
Q

shift

A

recombination involving entire genome segment encoding H or N

37
Q

most important for pandemics

A

antigenic shifts

38
Q

type A may appear in

A

endemic, epidemic, pandemic

39
Q

flu nomenclature

A

type/location of discovery/year of isolation/antigenic type

40
Q

2009 novel H1N1 swine flu

A

pandemic in Mexico due to unanticipated type of shift

41
Q

Chlamydiae

A

obligate intracellular parasites-remove ATP from host

42
Q

Chlamydiae tow forms

A

EB: elementary body, infectious non growing , dispersal RB: reticulate body, growing

43
Q

infant pneumonia cause

A

Chlamydiae trachomatis (3 weeks after birth, rhinitis and cough)

44
Q

what complication after infection w/Chlamydiae trachomatis

A

Reiter’s syndrome

45
Q

C. pneumoniae

A

TWAR, bronchitis, pneumonia, sinusitis

46
Q

C. pneumoniae a/w

A

atherosclerosis

Micro Exam 2 (4 decks)

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