RTI- RSV &PIV

Question 1

croup definition

Answer 1

1. syndrome of fever, hoarseness, barking cough in children 6-18 months of age
2. complication of URTI –>tracheal constriction below the vocal cords

Question 2

cause of croup

Answer 2

PIV type one>PIV type 2»>RSV

Question 3

Parainfluenza viruses

Answer 3

Paramyxovirus: RSV, measles, mumps

Question 4

PIV

Answer 4

paramyxovirus, NON-SEGMENTED, negative sense ssRNA, enveloped

Question 5

PIV: hemagglutinin and neuraminidase activities on

Answer 5

same peplomer molecule

Question 6

PIV: Novel fusion proteins causes

Answer 6

syncytia formation

Question 7

PIV replication site

Answer 7

upper respiratory tract epithelial cells (nasal turbinate and ciliated epithelium) -may invade lower airways

Question 8

symptoms of PIV

Answer 8

harsh cough, rhinitis, sore throat, SOB

Question 9

barking cough worse at night a/w

Answer 9

PIV croup

Question 10

PIV complications

Answer 10

Otitis media , parotitis

Question 11

type of PIV that is endemic

Answer 11

type 3

Question 12

type of PIV that exhibit epidemic periodicity and prevalent in children

Answer 12

types 1 and 2

Question 13

PIV immunity

Answer 13

Not lifelong-repeat infections w/ homotypic virus observed

Question 14

PIV dx

Answer 14

1. direct viral isolation from throat swabs 2. direct FAB test

Question 15

PIV tx

Answer 15

supportive, no vaccine

Question 16

RSV symptoms

Answer 16

cough,DYSPNEA, CYANOSIS, ~croup

Question 17

most common cause of infant croup

Answer 17

the closely related parainfluenza viruses type 1 and 2

Question 18

RSV symptoms

Answer 18

infection in epithelium of nose, throat, bronchi

Question 19

RSV most common in

Answer 19

infant 6-9 months of age

Question 20

RSV symptoms are due to

Answer 20

inflammatory response to infection via IgE and T cells

Question 21

RSV dx

Answer 21

1.rapid antigen test 2. immunofluorescence assay

Question 22

RSV Tx

Answer 22

monoclonal immune globulin for high risk pt (Palivizumab)

Question 23

most common etiology of lower respiratory tract infection in children under 4

Answer 23

SRV

Question 24

risk factors for SRV

Answer 24

underlying dz and premature births

Question 25

hospitalization for SRV epidemiology

Answer 25

2-3 months old ( born 3-4 months before RSV season -winter)

Question 26

SARS

Answer 26

coronavirus

Question 27

MERS

Answer 27

middle eastern -coronavirus

Question 28

coronavirus

Answer 28

GI and respiratory symptoms, zoonotic reservoirs, constant threat