Pneumonia I & II

Question 1

most common infectious cause of death

Answer 1

pneumonia

Question 2

causes of CAP - typical

Answer 2

S pneumo, K pneumo, H flu, S aureus

Question 3

3 non-zoonotic pathogens of atypical CAP

Answer 3

clamydia pneumo, mycoplasma pneumo, legionella pnemo

Question 4

CXR of pneumonia

Answer 4

typical: consolidation well defined atypical: patchy infiltrates non defined

Question 5

Strep pnemo (penmococcus)

Answer 5

G+, LANCENT shaped, dipli, alpha hemolytic (green), optochin sensitivity

Question 6

major resevoir of pnemococcus

Answer 6

asymptomatic carriers

Question 7

major virulant factor of pneumococcus

Answer 7

capsule-used for vaccine & serotyping

Question 8

capsule

Answer 8

inhibits phagocytosis and interfere with complement activity

Question 9

virulence factors of pneumococcus used for protection

Answer 9

IgA protease and hydrogen peroxide

Question 10

hydrogen peroxide

Answer 10

apoptosis of host cells

elimination of competing bacteria

Question 11

virulence factors of pneumococcus used for binding

Answer 11

pili and surface protein

Question 12

pili

Answer 12

colonization of the URT and activate production of large quantities of TNF

Question 13

surface protein

Answer 13

coline binding protein, adhesins - interact w. carbs on pulm epithelial cells

Question 14

virulence factor of pneumococcus causing significant immune response

Answer 14

peptidoglycan-teichoic acid complex

Question 15

virulence factor activating complement

Answer 15

pneumolysin-interacts w/target cell membrane, forms pores and lysis

Question 16

virulence factor in response of abx

Answer 16

autolysin -lysis of pneumococcus and release of pnemolysin

Question 17

purpose of autolysin

Answer 17

dampen host immune response

Question 18

purulant rust color sputum a/w

Answer 18

s pneumo

Question 19

s pneumo dissemination

Answer 19

bacteremia, meningitis, arthritis, peritonitis

Question 20

small round green colored colonies on blood agar

Answer 20

s pneumo (alpha hemolytic)

Question 21

not staining capsules

Answer 21

s pneumo

Question 22

confirmation bile solubility

Answer 22

s pneumo - bile lysis it

Question 23

quellung reaction test

Answer 23

s pneumo -to observe capsule

Question 24

does not grow near optochin

Answer 24

s pneumo

Question 25

dx for s pneumo

Answer 25

agglutination test for capsular poly sach.

genetic proble test for specific rRNA

Question 26

DOC of s pneumo

Answer 26

Pen G

Question 27

k pneumo causes

Answer 27

causes of both typical CAP and NP

Question 28

k pneumo

Answer 28

non motile, G-, bacillus , think slimy capsule

Question 29

k pneumo cause pneumonia mostly in

Answer 29

alcoholics and DM and homeless

Question 30

primary virulence factor in k pneumo

Answer 30

polysacharide capsule -adhesins is another

Question 31

k pneumonia results in

Answer 31

aggressive NECROTIZING CAP w/predilection of upper lobes -sever and rapid

Question 32

thick blood tinged sputum current jelly sputum is a/w

Answer 32

k pneumo

Question 33

cxr often reveals cavitation

Answer 33

k pneumo

Question 34

k pneumo tx

Answer 34

empiric therapy due to rapidly progressing dz then combination of aminoglycosides, 3rd gen cephal, fluoroquinolones