Pneumonia I & II Flashcards

1
Q

most common infectious cause of death

A

pneumonia

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2
Q

causes of CAP - typical

A

S pneumo, K pneumo, H flu, S aureus

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3
Q

3 non-zoonotic pathogens of atypical CAP

A

clamydia pneumo, mycoplasma pneumo, legionella pnemo

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4
Q

CXR of pneumonia

A

typical: consolidation well defined atypical: patchy infiltrates non defined

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5
Q

Strep pnemo (penmococcus)

A

G+, LANCENT shaped, dipli, alpha hemolytic (green), optochin sensitivity

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6
Q

major resevoir of pnemococcus

A

asymptomatic carriers

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7
Q

major virulant factor of pneumococcus

A

capsule-used for vaccine & serotyping

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8
Q

capsule

A

inhibits phagocytosis and interfere with complement activity

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9
Q

virulence factors of pneumococcus used for protection

A

IgA protease and hydrogen peroxide

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10
Q

hydrogen peroxide

A

apoptosis of host cells

elimination of competing bacteria

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11
Q

virulence factors of pneumococcus used for binding

A

pili and surface protein

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12
Q

pili

A

colonization of the URT and activate production of large quantities of TNF

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13
Q

surface protein

A

coline binding protein, adhesins - interact w. carbs on pulm epithelial cells

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14
Q

virulence factor of pneumococcus causing significant immune response

A

peptidoglycan-teichoic acid complex

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15
Q

virulence factor activating complement

A

pneumolysin-interacts w/target cell membrane, forms pores and lysis

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16
Q

virulence factor in response of abx

A

autolysin -lysis of pneumococcus and release of pnemolysin

17
Q

purpose of autolysin

A

dampen host immune response

18
Q

purulant rust color sputum a/w

19
Q

s pneumo dissemination

A

bacteremia, meningitis, arthritis, peritonitis

20
Q

small round green colored colonies on blood agar

A

s pneumo (alpha hemolytic)

21
Q

not staining capsules

22
Q

confirmation bile solubility

A

s pneumo - bile lysis it

23
Q

quellung reaction test

A

s pneumo -to observe capsule

24
Q

does not grow near optochin

25
dx for s pneumo
agglutination test for capsular poly sach. | genetic proble test for specific rRNA
26
DOC of s pneumo
Pen G
27
k pneumo causes
causes of both typical CAP and NP
28
k pneumo
non motile, G-, bacillus , think slimy capsule
29
k pneumo cause pneumonia mostly in
alcoholics and DM and homeless
30
primary virulence factor in k pneumo
polysacharide capsule -adhesins is another
31
k pneumonia results in
aggressive NECROTIZING CAP w/predilection of upper lobes -sever and rapid
32
thick blood tinged sputum current jelly sputum is a/w
k pneumo
33
cxr often reveals cavitation
k pneumo
34
k pneumo tx
empiric therapy due to rapidly progressing dz then combination of aminoglycosides, 3rd gen cephal, fluoroquinolones