Viral and Bacterial Oncogenesis

Question 1

HTLV-1 type

Answer 1

Human T-Cell Leukemia Virus Type 1

oncogenic RNA virus

Question 2

Japan, Caribbean, South America, Africa

Answer 2

HTLV-1 location

Question 3

HTLV-1 causes…

Answer 3

T-cell leukemia/lymphoma

Question 4

HTLV-1 encodes viral protein:

Answer 4

Tax protein:

1. turns on pro-growth and pro-survival pathways = polyclonal expansion of T cells
   2: increased genomic instability

Question 5

HPV type

Answer 5

Human Papilloma Virus

oncogenic DNA virus

Question 6

HPV causes…

Answer 6

benign warts, cervical cancer, oropharyngeal cancer, in particular - tumors from tonsillar mucosa

CERVICAL CARCINOMA AND HEAD/NECK CANCER

Question 7

HPV viral oncoproteins and what each binds to

Answer 7

E6 binds to p53

E7 binds to Rb

Question 8

EBV type

Answer 8

Epstein Barr Virus

oncogenic DNA virus

Question 9

EBV causes…

Answer 9

BURKITT LYMPHOMA

B-cell lymphomas in pt with T-cell immunosuppression

Question 10

HBV and HBC type

Answer 10

Hepatitis B/C virus

oncogenic DNA virus

Question 11

HBV causes…

Answer 11

70-80% of hepatocellular carcinomas

Question 12

HBV/HCV protein that causes carcinogenesis

Answer 12

HBx

Question 13

Helicobacter pylori causes

Answer 13

• gastric adenocarcinoma

- MALT lymphoma

Question 14

HBV/HCV endemic region

Answer 14

Far East and Africa

Question 15

H. pylori

Answer 15

BACTERIA

Question 16

Mechanism of carcinogenesis in HBV/HCV and H. pylori

Answer 16

Chronic Inflammation:
HBV/HCV - HEPATOCYTE death/regeneration over time
H. pylori - epithelial cell proliferation

Question 17

Merkel cell polyomavirus

Answer 17

oncogenic DNA virus

Question 18

HHV-8

Answer 18

Kaposi sarcoma herpesvirus

Question 19

HHV-8

Answer 19

Oncogenic DNA virus

Question 20

EBV infects

Answer 20

B lymphocytes, uses CD21 for attachment

Question 21

Burkitt Lymphoma endemic to

Answer 21

eastern Africa and New Guinea

Question 22

most common childhood tumor

Answer 22

Burkitt Lymphoma (EBV)

Question 23

Burkitt Lymphoma translocation

Answer 23

t(14;18)

Question 24

nasopharyngeal carcinoma

China, Africa, Inuit

Answer 24

associate with EBV

Question 25

E6 oncogenic activities

Answer 25

degrades p53 Arg72

CERVICAL CANCER

Question 26

E7 oncogenic activities

Answer 26

• binds to RB and displaces E2F&raquo_space; cycle proliferation
• inactivates CDK inhibitors p21 and p27
• inactivates cyclins E and A

Question 27

HPV associated expression oncogenic proteins that…

Answer 27

1. inactivate tumor suppressors
2. activate cyclins
3. combat cellular senescence