Viral and Bacterial Oncogenesis Flashcards
HTLV-1 type
Human T-Cell Leukemia Virus Type 1
oncogenic RNA virus
Japan, Caribbean, South America, Africa
HTLV-1 location
HTLV-1 causes…
T-cell leukemia/lymphoma
HTLV-1 encodes viral protein:
Tax protein:
- turns on pro-growth and pro-survival pathways = polyclonal expansion of T cells
2: increased genomic instability
HPV type
Human Papilloma Virus
oncogenic DNA virus
HPV causes…
benign warts, cervical cancer, oropharyngeal cancer, in particular - tumors from tonsillar mucosa
CERVICAL CARCINOMA AND HEAD/NECK CANCER
HPV viral oncoproteins and what each binds to
E6 binds to p53
E7 binds to Rb
EBV type
Epstein Barr Virus
oncogenic DNA virus
EBV causes…
BURKITT LYMPHOMA
B-cell lymphomas in pt with T-cell immunosuppression
HBV and HBC type
Hepatitis B/C virus
oncogenic DNA virus
HBV causes…
70-80% of hepatocellular carcinomas
HBV/HCV protein that causes carcinogenesis
HBx
Helicobacter pylori causes
- gastric adenocarcinoma
- MALT lymphoma
HBV/HCV endemic region
Far East and Africa
H. pylori
BACTERIA
Mechanism of carcinogenesis in HBV/HCV and H. pylori
Chronic Inflammation:
HBV/HCV - HEPATOCYTE death/regeneration over time
H. pylori - epithelial cell proliferation
Merkel cell polyomavirus
oncogenic DNA virus
HHV-8
Kaposi sarcoma herpesvirus
HHV-8
Oncogenic DNA virus
EBV infects
B lymphocytes, uses CD21 for attachment
Burkitt Lymphoma endemic to
eastern Africa and New Guinea
most common childhood tumor
Burkitt Lymphoma (EBV)
Burkitt Lymphoma translocation
t(14;18)
nasopharyngeal carcinoma
China, Africa, Inuit
associate with EBV
E6 oncogenic activities
degrades p53 Arg72
CERVICAL CANCER
E7 oncogenic activities
- binds to RB and displaces E2F»_space; cycle proliferation
- inactivates CDK inhibitors p21 and p27
- inactivates cyclins E and A
HPV associated expression oncogenic proteins that…
- inactivate tumor suppressors
- activate cyclins
- combat cellular senescence
