Selected Tumor Markers - Table 7-12

Question 1

**Hormone Marker: hcG

Answer 1

Trophoblastic tumors

Nonseminomatous testicular tumors

Question 2

Hormone Marker: calcitonin

Answer 2

medullary carcinoma of thyroid

Question 3

Hormone Marker: catecholamine and metabolites

Answer 3

pheochromocytoma and related tumors

Question 4

Hormone Marker: ectopic hormones

Answer 4

see “paraneoplastic syndromes” cards

Question 5

**Oncofetal Antigen Marker: alpha-fetoprotein

Answer 5

liver cell cancer

nonseminomatous germ cell tumor of testis

Question 6

Oncofetal Antigen Marker: carcinoembryonic antigen

Answer 6

CARCINOMAS: colon, pancreas, lung, stomach, heart

Question 7

Isoenzyme Marker: prostatic acid phosphatase

Answer 7

prostate cancer

Question 8

Isoenzyme Marker: neuron-specific enolase

Answer 8

small-cell cancer of the lung

Question 9

Specific Protein Marker: Ig (IgG and IgM mostly)

Answer 9

multiple myeloma and other gammopathies

Question 10

**Specific Protein Marker: prostate-specific antigen and prostate-specific membrane antigen

Answer 10

prostate cancer

Question 11

Mucins and other glycoprotein Markers:

1. CA-125
2. CA-19-9
3. CA-15-3

Answer 11

1. CA-125 - ovarian cancer
2. CA-19-9 - coloni cancer, pancreatic cancer
3. CA-15-3 - breast cancer

Question 12

Cell-free DNA Markers:

1. TP53, APC, RAS mutants in stool and serum
2. TP53 and RAS mutants in stool and serum
3. TP53 and RAS mutants in sputum and serum
4. TP53 mutants in urine

Answer 12

1. colon cancer
2. pancreatic cancer
3. lung cancer
4. bladder cancer