Paraneoplastic Syndromes - Table 7-11

Question 1

Types of paraneoplastic syndromes

Answer 1

• endocrinopathis
• nerve and muscle syndromes
• dermatologic disorders
• osseous, articular, and soft tissue changes
• vascular and hematologic changes
• others

Question 2

Paraneoplastic syndrome

Answer 2

signs and symptoms that cannot readily be explained by anatomic distribution of the tumor

Question 3

**Hypercalcemia

Answer 3

endocrinopathy type of Paraneoplastic syndrome

Question 4

**Neuromyopathic syndromes (2)

Answer 4

myasthenia and disorders of the CNS/PNS

Question 5

**Acanthosis nigrans

Answer 5

dermatologic disorder - blackened patched of hyperkeratotic skin

Question 6

**Forms of __ paraneoplasitic syndrome:
bronchogenic carcinoma
thymic neoplasms

Answer 6

Hypertrophic osteoarthropathy

Question 7

**causal mechanism of Hypertrophic osteoarthropathy

Answer 7

unknown

Question 8

**Forms of __ paraneoplasitic syndrome:
gastric carcinoma
lung carcinoma
uterine carcinoma

Answer 8

acanthosis nigricans (dermatologic disorder)

Question 9

**causal mechanism of acanthosis nigricans (dermatologic disorder)

Answer 9

immunologic; secretion of epidermal growth factor

Question 10

**Forms of \_\_ paraneoplasitic syndrome:
squamous cell carcinoma of lung
breast carcinoma
renal carcinoma
adult T-cell leukemia/lymphoma

Answer 10

hypercalcemia endocrinopathy

Question 11

**causal mechanism of hypercalcemia endocrinopathy

Answer 11

PTH-related protein, TGF-alpha, TNF, IL-1

Question 12

**Forms of __ paraneoplasitic syndrome:

breast carcinoma

Answer 12

Disorders of CNS/PNS - nn and mm syndromes

Question 13

1.  Forms of \_\_ paraneoplasitic syndrome:
Small-cell carcinoma of the lung
Pancreatic carcinoma
Neural tumors
2.  Causal mechanism:

Answer 13

1. cushing syndrome (endocrinopathy)

2. Cause: ACTH or ACTH-like substance

Question 14

1. Forms of __ paraneoplasitic syndrome:
   small-cell carcinoma of lung
   intracranial neoplasm
2. Causal mechanism:

Answer 14

1. Syndrome of inappropriate ADH secretion (endocrinopathy)

2. ADH or ANP

Question 15

1.  Forms of \_\_ paraneoplasitic syndrome:
ovarian carcinoma
fibrosarcoma
other emsenchymal sarcoma
2.  Causal mechanism:

Answer 15

1. Hypoglycemia (endocrinopathy)

2. Insulin or insulin-like substance

Question 16

1.  Forms of \_\_ paraneoplasitic syndrome:
renal carcinoma
cerebellar hemangioma
hepatocellular carcinoma
2.  Causal mechanism:

Answer 16

1. polycythemia (endocrinopathy)

2. EPO

Question 17

hematologic/vascular paraneoplastic syndrome:

migratory thrombophlebitis

Answer 17

Trousseau syndrome - associated with deep-seated cancers

CARCINOMAS of pancreas or lung

Question 18

hematologic/vascular paraneoplastic syndrome:

DIC

Answer 18

associated with acute promyelocytic leukemia and prostatic adenocarcinoma

Question 19

hematologic/vascular paraneoplastic syndrome:

nonbacterial thrombic endocarditis

Answer 19

Lesions of nonbacterial fibrinous vegetations on L cardiac valve
Associated with mucin-secreting adenocarcinomas