VIQ - TEST PAPER 2 Flashcards
@# 2.A 40-year-old man undergoes a CT scan of the abdomen for recurrent abdominal pain.
The precontrast scan showed bilateral renal calculi. A post-contrast scan showed severalpancreatic lesions, measuring between 1 and 2 cm. What is the likely unifying diagnosis?
A. MEN I
B. MEN IIA
C. Insulinoma
D. Glucagonoma
E. NF1
2.A. MEN 1
Multiple endocrine neoplasia Type 1 is also known as Wermer syndrome. Inheritance isautosomal dominant with high penetrance. The male to-female ratio is 1:1. Organ involvement includes parathyroid hyperplasia (97%), pancreatic islet cell tumour (30% 80%), anterior pituitary gland tumour (15%—50%) and adrenocortical hyperplasia (33%-40%).
@# 8. A slimly built 60-year-old woman presents with anorexia, diarrhoea, and weight loss. Barium meal shows multiple filling defects in the stomach with thickened gastric rugae. Colonoscopy shows multiple colonic polyps. The top differential is
A. Peutz-Jeghers syndrome
B. Familial adenomatous polyposis
C. Cronkhite-Canada syndrome
D. Cowden syndrome
E. Turcot’s syndrome
- C. Cronkhite-Canada syndrome
Cronkhite-Canada syndrome occurs in older patients with an average age of 60 with no familial predisposition.
The histologic appearance of the GI polyps resembles that of juvenile polyps, and they are characteristically distributed throughout the stomach.
They are commonly small, sessile and characterised by cystic dilatation of the glands and inflammation of the lamina propria.
Patients commonly present with abdominal pain, protein-losing diarrhoea, anorexia and weight loss. Dystrophic nail changes and alopecia usually appear after the onset of GI symptoms.
@# 14. A 70-year-old man presents with rectal bleeding. Flexible sigmoidoscopy shows a circumferential tumour in the upper third of the anal canal. An MRI performed for staging shows locoregional lymphadenopathy. The lymph node group most likely to be involved is
A. Superficial inguinal
B. Common iliac
C. Pudendal
D. External iliac
E. Paraortic
- A. Superficial inguinal
Metastatic spread to regional lymph nodes represents the most common mode of tumour spread from cancer of the anal canal and margin. Nodal metastasis is more likely in cases of larger tumour size or a poorly differentiated anal tumour. Metastasis most commonly occurs to the perirectal nodes, with inguinal nodal spread being the second most common location of nodal metastasis.
@# 20. A 76-year old woman with 6 months’ history of progressive weight loss and altered bowel habits is referred for a CT scan of the abdomen and pelvis. The examination shows several hypoattenuating lesions on Segments II and III of the liver that are highly suspicious for malignancy. Blood biochemistry with tumour markers shows a normal AFP and CA 19-9 but raised CEA. LFTs are minimally deranged. The case is discussed at MDT.
What is the most likely differential diagnosis and further management plan out of the options given?
A. Primary hepatocellular carcinoma - liver biopsy
B. Hepatic adenoma - liver resection
C. Probable lung cancer - CT chest
D. Metastatic renal carcinoma - renal biopsy
E. Metastasis from colonic adenocarcinoma colonoscopy
- E. Metastasis from colonic adenocarcinoma - colonoscopy
@# 22. Which statement is not associated with transient patellar dislocation?
A. The medial patellar retinaculum frequently demonstrates high T2W signal changes.
B. A tibial tuberosity to trochlear groove distance of <1.5 cm.
C. Trochlear dysplasia is a predisposing condition.
D. There is an increase in the ratio of the patellar tendon to the patellar length.
E. Bone contusions of the anterolateral aspect of the lateral femoral condyle.
- B. A tibial tuberosity to trochlear groove distance of <1.5 cm.
Transient patellar dislocation is the dislocation of the patella laterally and subsequent relocation.
Trochlear dysplasia, patella alta (increase in the ratio of the patella tendon to the patella length) and an increase in the tibial tuberosity trochlear groove (TT-TG) distance are associated factors.
TT-TG >20 mm is abnormal and 15-20 mm is considered borderline change.
TT-TG less than 15 mm is within normal limits.
Contusional marrow oedema is often seen in the medial patellar facet and the lateral femoral condyle.
The medial patellar retinaculum and/or medial patellofemoral ligament (MPFL) may be torn or show a pattern of strain injury.
@# 27. A young woman with a palpable nodule in the breast undergoes a contrast enhanced MRI breast for further evaluation. MRI demonstrates typical multiple non-enhancing internal septations. What is the diagnosis?
A. Fibrocystic change
B. Abscess
C. Atypia
D. Fibroadenoma
E. Hydatid cyst
- D. Fibroadenoma
Non-enhancing internal septations were initially described to have a high specificity in fibroadenoma diagnosis; however, this feature has recently been described in PTs and cancers and thus has little value when considered alone .Although morphological findings are important in lesion characterisation, breast cancers may have a benign appearance. In particular, 30% of familial breast cancers revealed a mass showing benign morphological features with a round or oval shape, smooth margins and homogeneous internal enhancement. It should be considered that all enhancing masses in women with genetic risks are suitable for biopsy when there is a lack of typical cyst or fat necrosis findings.
@# 31. A 66-year-old man with central chest pain radiating to the back is brought into the A&E department. A chest X-ray is read as unremarkable and a contrast CT is organised. The contrast CT shows an acute dissection flap in the aortic arch at the origin of the left common
carotid trunk extending through the descending thoracic aorta, into the proximal
abdominal aorta at the level of the renal arteries. Which of the following best classifies this dissection type?
A. DeBakey 1 - Stanford A
B. DeBakey 2 - Stanford A
C. DeBakey 3 - Stanford A
D. DeBakey 1 - Stanford B
E. DeBakey 2 - Stanford B
- A. DeBakey 1 - Stanford A
@# 33. All of the following are accepted indications for MRI breast in breast cancer imaging, except
A. Response to chemotherapy
B. Patients with breast augmentation
C. High-risk screening
D. Differentiate residual disease from post-surgical scar
F. . Breast cancer recurrence
- D. Differentiate residual disease from post-surgical scar
MRI of the breast has evolved into an important adjunctive tool with multiple indications in breast imaging, as recommended by US and European guidelines. Breast MRI is currently the most sensitive detection technique for breast cancer diagnosis. The indications are staging before treatment planning, screening of high-risk women, evaluation of response to neoadjuvant chemotherapy, patients with breast augmentation or reconstruction, occult primary breast cancer, breast cancer recurrence, identifying residual tumour in positive surgical margins and characterisation of equivocal findings. Differentiating early post-operative scarring from residual breast tumour is not possible because of similar enhancement characteristics of post-surgical scarring.
@# 37. An 8-week old boy presents with profound cyanosis with associated congestive cardiac failure. Imaging demonstrates a localised concurrent aortic coarctation. The likeliest underlying diagnosis would be
A. Tetralogy of Fallot
B. Truncus arteriosus
C. Transposition of the great arteries
D. Hypoplastic left heart syndrome
E. Tricuspid atresia
- D. Hypoplastic left heart syndrome
Hypoplastic left heart syndrome presents with early onset (days) of cyanosis and heart failure, leading to collapse and death in a few weeks of life. Associated cardiac malformations include pre- and post-ductal coarctation of the aorta, PDA, VSD, patent foramen ovale and so on.
Truncus arteriosus presents with minimal cyanosis in newborn infants; signs of heart failure are usually absent. Heart failure is evident in older infants.
Tetralogy of Fallot presents in early infancy with cyanosis, usually not present in early infancy, leading to clubbing; dyspnoea, heart failure, failure to thrive and paroxysmal hypercyanotic spells. X-ray shows a boot-shaped heart with oligaemic lungs.
Transposition of the great arteries is a medical emergency. Infants usually present in the first few hours or days with worsening duct-dependent cyanosis. Hypoxia is severe, but heart failure is not a feature. X-ray shows an ‘egg on end’ or ‘egg on string’ appearance.
Tricuspid atresia presents in the first few days of life with increasing cyanosis; other clinical features are dependent on associated PDA or VSD.
@# 38. All the following are useful features for differentiating true lumen from false lumen, except
A. In case of lumen wrapping, the inner lumen is true.
B. Beak sign indicates a false lumen.
C. A false lumen is often larger than a true lumen.
D. A cobweb sign demarcates the true lumen.
E. Intimal calcification surrounds the true lumen.
- D. A cobweb sign demarcates the true lumen.
The beak sign and a larger cross-sectional area were the most useful indicators of the false lumen for both acute and chronic dissections. Features generally indicative of the true lumen included outer wall calcification and eccentric flap calcification. In cases showing one lumen wrapping around the other lumen in the aortic arch, the inner lumen was invariably the true lumen. Outer wall calcification always indicated the true lumen on scans of acute dissections. False lumen thrombus was significantly more frequent in chronic dissections than acute dissections. Cobwebs are specific for the false lumen but are only rarely observed.
@# 41. A 74 year-old man presents with neck pain, with right upper-arm pain and radicular symptoms at the lateral aspect of the forearm and tingling in the thumb. What is the most likely finding on the MRI?
A. Central disc bulge at C3/4 with severe cord compression
B. Right foraminal disc osteophyte at C2/3
C. Right foraminal disc osteophyte at C4/5
D. Right foraminal disc osteophyte at C5/6
E. Right foraminal disc osteophyte at C3/4
- D. Right foraminal disc osteophyte at C5/6
Lateral aspect of the forearm and the thumb corresponds to the C6 dermatome. Foraminal osteophyte at C5/6 will impinge upon the exiting C6 nerve root. (cf. foraminal osteophyte at a thoracic or lumbar level, e.g., T4/5 or L4/5, which will impinge upon the exiting T4 or L4 nerve roots, subject to the discrepancy between number of cervical vertebra and cervical roots. Note that the exiting root at C7/T1 is C8.)
@# 42. A 35-year-old man involved in a major RTA undergoes a lateral view of the cervical spine m the resus on arrival. All of the following are features associated with atlanto occipital dislocation, except
A. Soft-tissue swelling anterior to C2 by >10 mm.
B. Basion dens interval >12 mm.
C. Odd’s ratio >1.
D. X-ray can often be normal.
E. Incongruity of articular surface of atlas and occipital condyles.
- D. X-ray can often be normal.
Atlanto-occipital dislocation shows the following on lateral radiograph of the cervical spine: >10 mm soft-tissue swelling anterior to C2, with pathological convexity (80%), basion-dens interval of >12 mm, odd’s ratio (distance between the basion and the posterior arch of the atlas divided by opisthion and anterior arch of atlas) >1, and basion-posterior axial line interval >12 mm anterior/>4 mm posterior to axial line.
Direct signs include loss of congruity of articular surfaces of atlas and occipital condyle. Normal X-ray in the presence of atlanto-occipital dislocation is rare.
@# 43. A child presents with an abnormally shaped cranium. There is hypertelorism and the skull vault appears short and widened. The anterior cranial fossa appears shortened. Which sutures are likely to have fused early?
A. Sagittal
B. Coronal
C. Metopic
D. Lambdoid
E. Unilateral coronal and lambdoid
- B. Coronal
The appearance here describes brachycephaly. Craniosynostosis is the premature fusion of cranial sutures and may be isolated or may present as part of a craniofacial syndrome. It typically alters the shape of the cranial vault. Broad categories include simple craniosynostosis, involving only one suture, or compound craniosynostosis, where two or more sutures are involved.
@# 44. A 37 year old woman with newly diagnosed hypertension undergoes an MRA, which shows alternate areas of stricture and dilatation to the right renal artery, sparing the origin. Which of the following is the least likely association?
A. String-of-beads appearance of the contralateral renal artery
B. String-of-beads appearance of the extracranial internal carotid artery
C. String of-beads appearance of the retinal artery
D. String-of-beads appearance of the vertebral artery
E. String-of-beads appearance of the SMA
- C. String-of-beads appearance of the retinal artery
Fibromuscular dysplasia (FMD) is an idiopathic, segmentary, non-inflammatory and non atherosclerotic disease that can affect all layers of both small- and medium-calibre arteries. Vascular loops, fusiform vascular ectasia and a string-of-beads aspect are typical presentations. Arterial dissection, aneurysm and subarachnoid haemorrhage are less typical radiologic presentations.
The affected arteries are mainly the renal arteries, extracranial carotid and vertebral arteries, mesenteric arteries and intracranial carotid arteries. Central retinal artery occlusion is a rarely recognised feature of fibromuscular dysplasia.
@# 51. A 30-year-old woman who is 36 weeks pregnant is being evaluated with targeted ultrasound to investigate a recently noticed breast lump. Ultrasound images are reported to show a well-circumscribed, wider than tall, hypoechoic, solid mass corresponding to the abnormality. Follow-up imaging to assess stability shows progressive regression in size of the mass post-partum. What is the likely diagnosis?
A. Fibrocystic change
B. Fat necrosis
C. Inflamed intramammary node
D. Lactating adenoma
E. Breast hamartoma
- D. Lactating adenoma
Lactating adenomas are newly discovered painless lumps that appear during the third trimester or lactation. They are a freely mobile, homogenous hypoechoic or isoechoic mass with posterior acoustic enhancement (most common) and septa. The lesion regresses after breastfeeding.