Vinca Alkaloids/ Mitotic Inhibitors/ DRUGS Flashcards
Inhibit polymerization of microtubules
OR
Enhancement of microtubule polymerization and prevention of their degradation BOTH lead to ….
MITOSIS INHIBITED
Vinca Alkaloids arrests the cell in _______________ & leads to cell death.
METAPHASE
The mechanism of _________________ drug is to bind to tubulin to prevent polymerization and inhibit microtubule production & mitotic spindle assembly.
VINCRISTINE
The mechanism of ______________ drug is to bind to Beta tubulin and inhibit the polymerization into microtubules.
VINBLASTINE
What is the main dose-limiting toxicity of VINCRISTINE?
NEUROTOXICITY (e.g. peripheral sensory neuropathy) “stocking-glove distribution”
Which vinca alkaloid treats breast cancer and germ cell cancer?
VINBLASTINE
VINBLASTINE treats ___________ & _______________ cancer
BREAST & GERM CELL CANCER
Which vinca alkaloid treats ALL, multiple myeloma, Hodgkin’s/ NON-Hodgkin’s?
VINCRISTINE
Which vinca alkaloid treats the following pediatric tumors:
- Rhabdomyosarcoma
- Neuroblastoma
- Ewing sarcoma
- Wilm’s tumor
VINCRISTINE
VINCRISTINE & VINBLASTINE both have the toxicity of ______________?
ALOPECIA
Which vinca alkaloid contains the following toxicities?
- areflexia
- peripheral neuritis
- PARALYTIC ILEUS (constipation)
- orthostatic hypertension
- urinary retention
VINCRISTINE
What is the toxicity of VINBLASTINE?
MYELOSUPPRESSION
Which drugs bind directly to microtubules and are known as the “cytotoxic plant alkaloids” ?
TAXANES
- Paclitaxel
-Docetaxel
What is the mechanism of action of the TAXANES?
TAXANES enhance microtubule production and prevent their degradation → improper mitotic spindle function
Which drug inhibits cellular proliferation by stabilizing existing microtubule assembly (enhancing microtubule polymerization) & prevents their degradation?
TAXANES
- Paclitaxel
-Docetaxel
In contrast to vinca alkaloids, taxane chemotherapeutics ___ microtubule assembly and ___ their degradation.
A. Destabilize, prevent
B. Destabilize, promote
C. Stabilize, prevent
D. Stabilize, promote
C. Stabilize, prevent
“Foot drop” or slapping gait is characteristic of which drug?
Vinca alkaloids (VINCRISTINE)
