Vinca Alkaloids/ Mitotic Inhibitors/ DRUGS Flashcards
Inhibit polymerization of microtubules
OR
Enhancement of microtubule polymerization and prevention of their degradation BOTH lead to ….
MITOSIS INHIBITED
Vinca Alkaloids arrests the cell in _______________ & leads to cell death.
METAPHASE
The mechanism of _________________ drug is to bind to tubulin to prevent polymerization and inhibit microtubule production & mitotic spindle assembly.
VINCRISTINE
The mechanism of ______________ drug is to bind to Beta tubulin and inhibit the polymerization into microtubules.
VINBLASTINE
What is the main dose-limiting toxicity of VINCRISTINE?
NEUROTOXICITY (e.g. peripheral sensory neuropathy) “stocking-glove distribution”
Which vinca alkaloid treats breast cancer and germ cell cancer?
VINBLASTINE
VINBLASTINE treats ___________ & _______________ cancer
BREAST & GERM CELL CANCER
Which vinca alkaloid treats ALL, multiple myeloma, Hodgkin’s/ NON-Hodgkin’s?
VINCRISTINE
Which vinca alkaloid treats the following pediatric tumors:
- Rhabdomyosarcoma
- Neuroblastoma
- Ewing sarcoma
- Wilm’s tumor
VINCRISTINE
VINCRISTINE & VINBLASTINE both have the toxicity of ______________?
ALOPECIA
Which vinca alkaloid contains the following toxicities?
- areflexia
- peripheral neuritis
- PARALYTIC ILEUS (constipation)
- orthostatic hypertension
- urinary retention
VINCRISTINE
What is the toxicity of VINBLASTINE?
MYELOSUPPRESSION
Which drugs bind directly to microtubules and are known as the “cytotoxic plant alkaloids” ?
TAXANES
- Paclitaxel
-Docetaxel
What is the mechanism of action of the TAXANES?
TAXANES enhance microtubule production and prevent their degradation → improper mitotic spindle function
Which drug inhibits cellular proliferation by stabilizing existing microtubule assembly (enhancing microtubule polymerization) & prevents their degradation?
TAXANES
- Paclitaxel
-Docetaxel
