ANTItumor ANTIbiotic/ DRUGS

Question 1

What drug is represented here?

Answer 1

BLEOMYCIN === BELUGA WHALE

Question 2

Which drug’s mechanism of action is to bind to DNA and chelates metal ions producing a pseudo-enzyme that reacts with oxygen to produce free radicals that cleave DNA?

Answer 2

BLEOMYCIN

Question 3

What’s bleomycin’s mechanism of action?

Answer 3

Oxygen free radicals bind to DNA and create SINGLE & DOUBLE DNA strand breaks.

Question 4

Bleomycin gets arrested in the _____________ phase of the cell cycle?

Answer 4

G2

Question 5

What’s the dose-limiting toxicity of Bleomycin?

Answer 5

PULMONARY TOXICITY
(pneumonitis, pulmonary infiltrates)

Question 6

Pulmonary Toxicity for Bleomycin consists of what symptoms?

Answer 6

-pneumonitis with cough
- dyspnea
-crackles/rales
-infiltrates

Question 7

Which drug has the toxicity of skin redness, hyperpigmentation, and skin tenderness?

Answer 7

BLEOMYCIN

Question 8

Which drug has the toxicity of rash, exfoliation, and atrophic striae?

Answer 8

BLEOMYCIN

Question 9

Which drug has the toxicity of alopecia?

Answer 9

BLEOMYCIN

Question 10

Which drug has the toxicity of stomatitis and mucositis?

Answer 10

BLEOMYCIN

Question 11

List the anthracyclines

Answer 11

• DOXORUBICIN
• DAUNORUBICIN
• EPIRUBICIN

Question 12

What’s the mechanism of action of anthracyclines?

Answer 12

1) Inhibit topoisomerase II
2) High-affinity binding of DNA through intercalation, with blockade of DNA and RNA synthesis.

Question 13

Which drug’s mechanism of action is to high-affinity binding of DNA through intercalation, with blockade of DNA and RNA synthesis?

Answer 13

ANTHRACYCLINES
- doxorubicin
-daunorubicin

Question 14

Which anthracycline treats a broad range of solid and hematologic malignancies?

Answer 14

DOXORUBICIN

Question 15

Which drug is an iron chelating agent used to prevent cardiotoxicity?

Answer 15

DEXRAZOXANE

Question 16

Anthracyclines can cause _______________ toxicity?

Answer 16

CARDIOTOXICITY (dilated cardiomyopathy)

• Acute: pericarditis, arrhythmia, ECG changes
• Chronic: Chronic Heart Failure

Question 17

What is the dose-limiting toxicity of athracyclines?

Answer 17

MYELOSUPPRESSION

Question 18

Which drugs can cause alopecia?

Answer 18

• BLEOMYCIN
• DOXORUBICIN

Question 19

Which antitumor antibiotics can cause myelosuppression?

Answer 19

ANTHRACYCLINES (e.g. doxorubicin) and ACTINOMYCIN D can cause myelosuppression

Question 20

Which drug intercalates in DNA → block DNA and RNA synthesis?

Answer 20

ACTINOMYCIN D/ DACTINOMYCIN

Question 21

What is this drug in sketchy?

Answer 21

ACTINOMYCIN D (antitumor antibiotic)

Question 22

What does ACTINOMYCIN D treat?

Answer 22

Pediatric malignancies (e.g. Wilms tumor, Ewing sarcoma, rhabdomyosarcoma)