Antimetabolites/ DRUGS

Question 1

Cladribine is a ______________ analog

Answer 1

PURINE

Question 2

Cytarabine is a pyrimidine ____________ analog

Answer 2

PYRIMIDINE

Question 3

What is the main toxicity of cladribine?

Answer 3

MYELOSUPPRESSION

Question 4

Cladribine causes a decrease in B or T lymphocytes?

Answer 4

T LYMPHOCYTES

• decrease in CD4 & CD8 T cells

Question 5

A decrease in T lymphocytes, increases the risk of ______________ ?

Answer 5

INFECTIONS

Question 6

This drug is converted to deoxyadenosine triphosphate?

Answer 6

CLADRIBINE

Question 7

Which drug is resistant to adenosine deaminase?

Answer 7

CLADRIBINE

… leads to increase in intracellular Cladribine levels.

Question 8

What is the mechanism of action of Cladribine?

Answer 8

1.) Incorporated into the the DNA synthesis pathway and causes breaks

Question 9

Which drug inhibits DNA polymerase alpha & beta (synthesis and repair)?

Answer 9

CLADRIBINE

Question 10

Cladribine treats _____________ leukemia.

Answer 10

HAIRY CELL

Question 11

Cladribine & Cytarabine are arrested in _________ phase of the cell cycle.

Answer 11

S PHASE

Question 12

What is the MAIN & associated toxicities of the drug Cytarabine?

Answer 12

MYELOSUPPRESSION
- cerebellar ataxia
- nausea and vomit
- neutropenia
-thrombocytopenia

Question 13

This drug inhibits ribonucleotide reductase & is a pyrimidine analog?

Answer 13

CYTARABINE

Question 14

The toxicities of Fludarabine?

Answer 14

MYELOSUPPRESSION
- fever
-myalgia(s)/arthralgia(s)

Question 15

Cytarabine treats which type of malignancies?

Answer 15

HEMATALOGIC:

(AML & non-Hodgkin lymphoma)