Platinum Analogs/ DRUGS Flashcards
What is the mechanism of action of the platinum analogs?
Binds to DNA & creates interstrand and intrastrand cross-links. (helix)
List the platinum analogs.
- CISPLATIN
-CARBOPLATIN
-OXALIPLATIN
What does cisplatin treat?
Sold malignancies (lung-cancer, testicular, ovarian, & bladder cancer)
Which platinum analog has the toxicities of ototoxicity (tinnitus) and peripheral neuropathy in stocking glove formation containing numbness, parathesias, and pain?
CISPLATIN
Which platinum analog has the toxicities of ototoxicity (tinnitus) and peripheral neuropathy in stocking glove formation containing numbness, parathesias, and pain?
CISPLATIN
Cisplatin causes acute _____________ injury?
acute kidney injury
What is this picture depicting?
Platinum analogs can cause ACUTE TUBULAR NECROSIS
ATN - muddy brown casts
What can prevent cisplatin-induced nephrotoxicity?
AMIFOSTINE
What is the function of AMIFOSTINE?
Scavenges free radicals in the kidney
What is the primary approach in reducing cisplatin-induced nephrotoxicity?
IV SALINE DIURESIS
Which platinum analog has the dose limiting toxicity of bone marrow suppression (myelosuppression)?
CARBOPLATIN
Which platinum analog is less nephrotoxic than cisplatin?
CARBOPLATIN
Which platinum analog has the toxicity of irreversible tingling numbness?
OXIPLATIN
Which platinum analog has the toxicity of intense pain and toxicity to cold?
OXIPLATIN
