Vestibular Disorders Flashcards

1
Q

NOT IN BOOK: Explain the physiology of the vestibular organ

A

The inner ear is separated to the anterior cochlear part and the posterior vestibular part. The vestibular part is composed of 3 parts. 3 semicircular canals positioned 90 degress from each other responsible for angular acceleration (e.g. head rotation) and 2 otolith organs, the urticle and the saccule responsible for linear acceleration (Horizontal and vertical respectively).

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2
Q

NOT IN BOOK: How does the vestibular organ detect movement/acceleration and how is it interpreted?

A

The vestibular organ contains an endolymph which shifts on movement => shifting of Cuplia (semicircular canals) and Otoconia (linear) => hair cells stimulated => vestibular nerve => Vestibulocochlear nerve => Vestibular nuclei in brainstem

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3
Q

NOT IN BOOK: What is the meant by peripheral and central vestibular system?

A

Peripheral = 3 semicircular canals + urticle + saccule
Central = Cerebellum + spinal cord + Temporal love cortex

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4
Q

NOT IN BOOK What are the 2 main vestibular reflexes?
What tests are used to assess these reflexes?

A

Vestibulo-ocular -> Maintains optical fixation during head movement
Tested via Head Impulse Test

Vestibulospinal -> Senses head movement and position relative to gravity
Tested via Romberg or Unterberger/Fukuda Test

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5
Q

An individual’s balance depends on 3 sensory inputs. List them and state the one which the body is most dependent on.

A

1) Visual input (70%)
2) Proprioception (15%) - central
3) Vestibular input (15%) - Peripheral
2/3 are required for balance

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6
Q

Differentiate dizziness from vertigo
Then Differentiate Dysequilibrium from Dysmetria

A

Dizziness = encompasses vertigo, presyncope, dysequilibrium, dysmetria
Vertigo is the sensation that the environment is spinning around one’s self when no movement exists

Dysequilibrium = inability to balance one’s self or unsteady
Dysmetria is the inability to approximate

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7
Q

List the causes of vertigo/list vestibular disorders

A

Peripheral: BPPV, Meniere’s Disease, Viral Labyrinthitis, Acoustic Neuroma, Fistula from Cholesteatoma
Peripheral => ENT => not an emergency

Central: Migranous vertigo, Brainstem (TIA, Cerebellar stroke, Chiari malformations (spina bifida), Multiple Sclerosis)
Central => neuro => emergency

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8
Q

How can you differentiate between a central and peripheral cause of vertigo? Why?

A

HINTS Examination which involves the head impulse test, nystagmus test, and the test of skew to determine the cause. It is important to differentiate because central causes of vertigo are likely to be an emergency whereas peripheral causes are not

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9
Q

What is HINTS used for? What tests are involved in HINTS? What would be required according to the HINTS criteria to determine that the patient has a central cause of vertigo and requires immediate attention?

A

HINTS involves head impulse test, nystagmus test, and the test of skew to assess if the cause of sudden onset vertigo is central (hence requiring urgent attention) or peripheral
if 1/3 tests indicate a central cause then urgent attention with 98% specificity (super accurate)

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10
Q

Quick Hx for patient presenting with vertigo/dizziness

A

Episodical vs constant
Duration + frequency of episode (if episodical)
Triggering factors (rolling over, URTI, head injury, car, boat)
Associated Sx: headache, eye sx (red flag)!!!, Nausea/vomiting, palpitations, SOB, Syncope
Associated Ear sx: Tinnitus, hearing loss + type -> location of pathology
Neurological complaints (hemiparesis, cranial nerve…)
Past medical hx of cardio, neuro, opthalmo, rheumatological, migraines!
New medications!! (very good to specifically ask this in any hx)

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11
Q

Give the most likely diagnosis for a patient presenting with episodic vertigo, each lasting
seconds-minutes:
Minutes-hours:
days-weeks:
Constant and longstanding:

A

seconds-minutes: BPPV
Minutes-hours: Meniere’s or Vestibular neuritis
days-weeks: Viral Labyrinthitis
Constant and longstanding: Vestibular schwannoma

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12
Q

How would you describe an observed nystagmus to a consultant

A

Nystagmus observed on the right eye with right horizontal nystagmus. This would indicate that it is the right eye with the rapid phase being towards the right and slow to the left.

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13
Q

READ: You have a patient presenting with vertigo/dizziness. Imagine this is a long case station, now go through what you will do in the examination portion and then the main investigations you would order

A

1) Inspection head and neck with palpation of cervical lymph nodes…
2) ENT - Otoscopy, Hearing (Whisper, rinne, weber)
3) Neurological: Gait, Full Cranial Nerve Exam, Cerebellar testing including Past-pointing and Dysdiadokinesis, Fistula test, HINTS (Head impulse, nystagmus, and Test of Skew)
4) Vestibular: Dix-Hallpike Manouvre, Romberg Test, Unterberger test

Investigations:
1) Pure Tone Audiogram
2) Vestibular function tests
3) MRI of IAM!! and Brain !!

You can organize them how you will cuz many overlap. Whats important is that you are categorizing at all

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14
Q

What is the Fistula Test?
What pathology is this most important for?

A

Test for the presence of a fistula between middle and inner ear by applying pressure on the tragus and observe for nystagmus. This is particularly important for patients with cholesteatoma.

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15
Q

What is the Head Impulse Test and how would you conduct it and interpret your findings.
How would you interpret the findings in a patient with vertigo?

A

The Head impulse test is used to assess the vestibulo-ocular reflex involved in maintaining eye position on head movement. This is conducted by having the patient in front of you at eye-level and ask them to keep eyes open, looking at examiner’s nose. Move head to one direction quickly and observe for nystagmus or a !Corrective Saccade (eye returning to correct position). !!!Must state that it will be repeated on other side!!!
If patient maintains optical positioning => reflex preserved => -ve => Normal or central cause of vertigo in HINTS
If corrective saccade observed=> reflex not preserved => +ve => Peripheral cause of vertigo in HINTS

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16
Q

How would you assess for Nystagmus? How would you interpret your findings?
How would you interpret your findings in the case of a patient presenting with vertigo?

A

Assess nystagmus by moving finger quickly after asking patient to follow finger. or ask to quickly look to one direction and then return (and then repeat for other side).
When observing nystagmus, you must assess which eye it is involved in (or both) and which direction the rapid phase is.
e.g. Unidirectional = When looking to left, rapid phase to left. When looking right, rapid phase to the left
Bidirectional: When looking left, rapid phase to the left, when looking right, rapid phase to the right.

If No nystagmus => normal
Unidirectional Horizonal Nystagmus => Peripheral cause of vertigo in HINTS
Bidirectional/vertical/rotatory/direction-changing => Central cause of vertigo in HINTS

17
Q

How would you conduct the Test of Skew in a patient presenting with Vertigo?

A

Test of Skew is conducted by asking the patient to look at nose with both eyes open. Examiner covers one eye and then quickly covers the other looking for correction.
Vertical correction would indicate a central cause of vertigo.

18
Q

A patient presents to the ED with sudden onset vertigo. You are asked to determine if the patient needs urgent attention. How would you triage this patient?
If determined that the patient needs urgent attention what would you order and who will you consult?

A

HINTS examination to assess if patient has central or peripheral cause of vertigo.
If any of the following are true, the patient will need urgent attention

1) HIT - Head impulse test -> If patient has vertigo + reflex preserved on both sides (-ve test) -> may be central
2) Nystagmus - Assess for nystagmus -> Vertigo + Bidirectional/vertical/rotatory/direction-changing -> central
3) TS -Test of Skew - Vertigo + Vertical correction => central

Consult Neurology and Non-contrast CT brain why? -> central cause => stroke/TIA/Chiari malformation/MS

19
Q

A 45 year old patient presents with sudden episodical vertigo lasting 20-30s on sudden head movement. What is the most likely diagnosis?
How will you confirm the diagnosis?
How will you manage this patient?

A

BPPV - Benign Paroxysmal Positional Vertigo
Dx = Positive Dix-Hallpike Test
Tx = Perform and teach Epley’s Manouvre

20
Q

What is the Dix Hallpike Manouvre used for?
How will you explain this to a patient in order to obtain consent?
How is it performed?

A

The Dix Hallpike Test is used to diagnose BPPV
This is a routine manouvre with people experiencing this type of dizziness. I will ask you to cross your arms and look at me before lowering you down till you are lying down flat. This may make you dizzy but please try your best to keep your eyes open. !I will be holding your head in place during the entire manouvre!

Patient crossing arms looking 45 degrees towards examiner on asymptomatic side while seated on bed for 30s. Hold patient’s head in place with both hands throughout entire manouvre-> then lowered to supine and head extended 20 degrees off edge of bed. Hold in place and observe for nystagmus for 1 minute. !Then repeat test on other side!

21
Q

What is the Epley Manouvre used for?
How is it performed?

A

Used in the treatment of BPPV

Hold patient’s head for the entirety of the procedure. Begin with patient crossing arms looking 45 degrees towards examiner on asymptomatic side first while seating on bed for 30s. Then lower down with head 20 degrees off the bed for 30s until nystagmus resolves. Then turn head 180 degrees (to become 45 degrees on other side) -> ask to relax arms and turn on their side with their head still held in same position. Then ask to sit back up with head in the opposite direction of where it started.

22
Q

NOT IN BOOK: Meniere’s Disease:
What is the known pathophysiology causing Meniere’s disease?
What is the Tetrad of Meniere’s Disease? Other sx?
What is the workup if a patient presents with this tetrad?
What is your full tx ladder?

A

Meniere’s disease is a disorder of the inner ear of no known cause. !!!Endolymphatic Hydrops causing increased pressure in endolymphatic space => SNHL

Tetrad of Tinnitis, Vertigo, Aural Fullness, SNHL (starting unilateral + fluctuant to Bilateral + constant)
Other sx include: Nystagmus, Nausea/vomitting, Dysequilibrium, Dysmetria

As with most things in ENT:
1) Pure Tone Audiometry (showing unilateral low frequency SNHL)
2) MRI IAM
3) Video Nystagmography for vertigo

Tx: its hard, I know.
Conservative: Dietary (salt and fluid restriction), vestibular physiotherapy, hearing aids
Medical: Loop Diuretics (Bendrofluazide), Anti-vertigo (Betahistine), Short-term vestibular sedatives (Prochlorperazine)
Surgical if debilitating: Intratympanic steroid + Gentamicin injection -> Endolymphatic sac surgery

23
Q

NOT IN BOOK: What is the expected finding on Pure Tone Audiometry of Meniere’s disease?

A

Unilateral SNHL => Unilateral AC and BC lower
Pattern of HL is Lower frequency first in Meniere’s disease => Lower frequencies affected more initially

24
Q

What is the primary location of acoustic neuroma/vestibular schwannoma?

A

Cerebellopontine angle

25
Q

Define acoustic neuroma/vestibular schwannoma

A

Common Benign tumour of the !Cerebellopontine angle arising from !Schwann cells (=>peripheral)

26
Q

All cases of unilateral SNHL should receive what investigation?

A

All should receive MRI IAM (T2 or T1 w/gadolinium). This is essential to rule out acoustic neuroma/vestibular shwannoma. Come to think of it, even for unilateral conductive with any suspicion of cholesteatoma as well.

27
Q

Bilateral acoustic neuromas are seen in what disease?

A

Neurofibromatosis type 2

28
Q

What is the definitive management of acoustic neuroma/vestibular schwannoma?

A

Stereotactic radiosurgery or surgical excision

29
Q

A 48 year old patient presents to the OPD with a 1 month hx of constant vertigo. You conduct a Rinne and Weber test and determine AC>BC on both sides with lateralization to the left. The patient has a family history of Neurofibromatosis Type II. Answer the following questions:
How would you interpret the results of the Rinne and Weber Test?

What is the most likely diagnosis here?

What other symptoms or complications are missing in this history that would support the diagnosis?

Would you expect this to be unilateral or bilateral why?

What investigations will you perform?

How would you manage this patient?
Given that this patient has Neurofibromatosis Type II, what is the likely progression of this disease?

A

Rinne and Weber test indicate unilateral sensorineural hearing loss on the right ear

Most likely diagnosis = Acoustic Neuroma/Vestibular Schwannoma

Other Sx or complications: Tinnitus, compress nerves CNV, CNVII (facial twitching, weakness, change in taste, change in tear production), , mass effect (headache, nausea, vomiting, diplopia)

I would expect this to be bilateral (although in this case unilateral due to high a/w neurofibromatosis T2)

Workup: Full hx and exam assessing manifestations of NFT2.
!!MRI IAM and Brain (T2/ T1 w/gadolinium) - looking at both IAMs
Pure tone Audiometry (uni/bilateral hearing loss)

Conservative: Not for this patient -> repeat MRI in 6 months (its benign so it wont metastasize, => watchful waiting to see if more sx arise and necessity for surgery rises)
Stereotactic radiosurgery or !Surgical excision by neurosurgery

NF Type 2 patients will typically have bilateral SNHL

30
Q

In total, what is the clinical presentation of acoustic neuroma/vestibular schwannoma?

A

Unilateral SNHL
Tinnitus & Vertigo
Facial nerve palsy (facial twitching, weakness, change in taste, change in tear production)
sx of raised ICP (N+V, Headaches, papilloedema, altered conciousness, lethargy…)

31
Q

What is an acoustic neuroma?
Where is this tumour typically located?

A

It is a benign, locally destructive growth of Schwann cells on the Superior Vestibular Nerve of CNVIII.
Typically located in the Cerebellopontine angle/IAM