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Neurophisiology > Vesicle formation > Flashcards

Vesicle formation Flashcards

1
Q

Otto Loewi

A

Discovered acetylcholine

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2
Q

Where are neurotransmitters synthesized

A

Cell body or axon terminal

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3
Q

What are neurotransmitter packaged into

A

Synaptic vesicle

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4
Q

Neurot. are released from

A

axon terminal

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5
Q

Where do neurotransmitters bind

A

specific receptors on post synaptic membrane

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6
Q

Precursor peptide is synthesized…

A

In rough ER

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7
Q

Precursor peptide is split in

A

Golgi apparatus - Active NT

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8
Q

Secretory vesicles containing

A

peptide bud off from Golgi

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9
Q

Enzyme precursors to neurotransmitter

A

cytosol

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10
Q

transporter proteins load

A

neurotransmitter into synaptic vesicles

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11
Q

Peptide neurotransmitters

A
  • Cholecytstokinin (CKK)
  • Dynorphin
  • Enkephalin
  • Substance P
  • Large dense-core vesicles
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12
Q

Microtubules

A

bipolarization In the dendrites

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13
Q

Kinesin family

A

Anterograde; fast and slow

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14
Q

Dynein

A

Anterograde or retrograde; fast (mainly retrograde)

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15
Q

Vesicle membrane

A

Concentrates membrane proteins in a specialized patch

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16
Q

Type of coating in budding

A

Cathrin-mediated

17
Q

Adaptor proteins assemble

A

clathrin

18
Q

Pinches off membrane

A

Dynamin

19
Q

Phosphorlates snapsin

A

Ca2+ activates CA2+/CaMKII

20
Q

Purpose of phosphorylation of synapses

A

dissociates vesicles

21
Q

Mobilization from reserve pool to

A

membrane

22
Q

t-SNARES

A

SNAP25, Syntaxin

23
Q

v-SNARES

A

synaptobrevin

24
Q

vesicle docking

A

involves interaction with vesicle associated protein RAb3 and CM-associated protein

25
Q

Trafficking

A

Rab proteins direct vesicles to specific regions

26
Q

Specific regions of target membrane

A

GTPase

27
Q

Rab proteins bind to

A

Rab effectors

28
Q

Rab effectors facilitate

A

transport, teetering, and fusion

29
Q

v-SNARE snaptobrevin interacts with

A

t-SNARE syntaxin and SNAP25

30
Q

SNARE complex brings

A

vesicles membrane and PS closer

31
Q

synaptotagmin is in close apposition to

A

plasma membrane

32
Q

AP lead to Ca influx

A

Snaptoagmin acts as a C sensor

33
Q

AP leads to Ca influx

A

snaptotagmin acts as a Ca sensor

34
Q

Ca induces conformation change in SNARE

A

vesicles and plasma membrane fuse

35
Q

Ca binds to synaptotagmi

A

tight SNARE conformation

36
Q

Neurotoxin venom

A

a-Latrotoxin

37
Q

a-Latroxin

A

mimics Ca at presynapse

38
Q

Lotroxin causes massive release of

A

neurotransmitter acetylcholine

39
Q

Latrodectism symptoms

A

Muscle hyper-excitability, vomit, sweating, nausea, difficulty breathing

Neurophisiology (5 decks)

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