Vesicle formation

Question 1

Otto Loewi

Answer 1

Discovered acetylcholine

Question 2

Where are neurotransmitters synthesized

Answer 2

Cell body or axon terminal

Question 3

What are neurotransmitter packaged into

Answer 3

Synaptic vesicle

Question 4

Neurot. are released from

Answer 4

axon terminal

Question 5

Where do neurotransmitters bind

Answer 5

specific receptors on post synaptic membrane

Question 6

Precursor peptide is synthesized…

Answer 6

In rough ER

Question 7

Precursor peptide is split in

Answer 7

Golgi apparatus - Active NT

Question 8

Secretory vesicles containing

Answer 8

peptide bud off from Golgi

Question 9

Enzyme precursors to neurotransmitter

Answer 9

cytosol

Question 10

transporter proteins load

Answer 10

neurotransmitter into synaptic vesicles

Question 11

Peptide neurotransmitters

Answer 11

• Cholecytstokinin (CKK)
• Dynorphin
• Enkephalin
• Substance P
• Large dense-core vesicles

Question 12

Microtubules

Answer 12

bipolarization In the dendrites

Question 13

Kinesin family

Answer 13

Anterograde; fast and slow

Question 14

Dynein

Answer 14

Anterograde or retrograde; fast (mainly retrograde)

Question 15

Vesicle membrane

Answer 15

Concentrates membrane proteins in a specialized patch

Question 16

Type of coating in budding

Answer 16

Cathrin-mediated

Question 17

Adaptor proteins assemble

Answer 17

clathrin

Question 18

Pinches off membrane

Answer 18

Dynamin

Question 19

Phosphorlates snapsin

Answer 19

Ca2+ activates CA2+/CaMKII

Question 20

Purpose of phosphorylation of synapses

Answer 20

dissociates vesicles

Question 21

Mobilization from reserve pool to

Answer 21

membrane

Question 22

t-SNARES

Answer 22

SNAP25, Syntaxin

Question 23

v-SNARES

Answer 23

synaptobrevin

Question 24

vesicle docking

Answer 24

involves interaction with vesicle associated protein RAb3 and CM-associated protein

Question 25

Trafficking

Answer 25

Rab proteins direct vesicles to specific regions

Question 26

Specific regions of target membrane

Answer 26

GTPase

Question 27

Rab proteins bind to

Answer 27

Rab effectors

Question 28

Rab effectors facilitate

Answer 28

transport, teetering, and fusion

Question 29

v-SNARE snaptobrevin interacts with

Answer 29

t-SNARE syntaxin and SNAP25

Question 30

SNARE complex brings

Answer 30

vesicles membrane and PS closer

Question 31

synaptotagmin is in close apposition to

Answer 31

plasma membrane

Question 32

AP lead to Ca influx

Answer 32

Snaptoagmin acts as a C sensor

Question 33

AP leads to Ca influx

Answer 33

snaptotagmin acts as a Ca sensor

Question 34

Ca induces conformation change in SNARE

Answer 34

vesicles and plasma membrane fuse

Question 35

Ca binds to synaptotagmi

Answer 35

tight SNARE conformation

Question 36

Neurotoxin venom

Answer 36

a-Latrotoxin

Question 37

a-Latroxin

Answer 37

mimics Ca at presynapse

Question 38

Lotroxin causes massive release of

Answer 38

neurotransmitter acetylcholine

Question 39

Latrodectism symptoms

Answer 39

Muscle hyper-excitability, vomit, sweating, nausea, difficulty breathing