GPCR

Question 1

Dales principle

Answer 1

neuron has only one neurotransmitter

Question 2

Co-transmitters

Answer 2

2+ released from one nerve terminal

Question 3

3 criteria for neurotransmitter

Answer 3

synthesis and storage in presynaptic neuron
must be release by axon terminal
must produce postsynaptic change

Question 4

ionotropic receptors

Answer 4

component of transmitter-gated ion channels, in or out of neuron

Question 5

metabotropic receptors

Answer 5

PM, indirect influences on ion, connected to metabolic processes initiated during bindings

Question 6

structure of G-protein coupled receptors

Answer 6

polypeptide with 7-membrane spanning alpha-helices

Question 7

GPCR activate

Answer 7

cascade of enzyme-catalyzed reactions

Question 8

GPCR form

Answer 8

second messengers

Question 9

Second messengers

Answer 9

intracellular chemical messenger molecules that open or close ion channels in PSM

Question 10

cyclic adenosine monophosphate (cAMP)

Answer 10

common second messenger derived from ATP

Question 11

G-protein cascades

Answer 11

alpha or beta-gamma subunits dissociates and activates membrane bound enzyme

Question 12

Alpha subunits contains

Answer 12

GTPase

Question 13

G-protein subunits

Answer 13

alpha, beta-gamma

Question 14

Different g-proteins

Answer 14

stimulate or inhibit adenylate cyclase

Question 15

G-protein subunits is activated by

Answer 15

GDP to GTP exchange

Question 16

G-protein activates

Answer 16

adenylate cyclase

Question 17

Adenylate cyclase activates

Answer 17

cAMP

Question 18

cAMP activated

Answer 18

ion channels via phosphorylation

Question 19

acetylecholine

Answer 19

basic schema of classical neurotransmitter signaling is typified

Question 20

inotropic receptor typified by

Answer 20

nicotinic acetylcholine

Question 21

complete pentameric structure forms

Answer 21

ion pore and ligand binding sites

Question 22

2 molecules of Act required to

Answer 22

open channel portion of inotropic receptors

Question 23

(-) charged amino acids at

Answer 23

pore loop initially attract ions

Question 24

structure/function of metatropic receptor is typified by

Answer 24

Muscarinic Ach receptors