GAMMA AND GABA

Question 1

Gamma-aminobutyric acid (GABA)

Answer 1

Primary inhibitory neurotransmitter

Question 2

Gaba is synthesized from

Answer 2

glutamate

Question 3

GAD- catalyzes reactions

Answer 3

glutamic acids decarboxylase

Question 4

Required for synthesize and catalyzing

Answer 4

co-factor pyridoxal phosphate

Question 5

VIATT

Answer 5

vesicular inhibitory amino acids transporter

Question 6

GABA is removed via

Answer 6

GAT transporter

Question 7

GAT transporter aka

Answer 7

Na transporter

Question 8

GABA is broken down into

Answer 8

succinate

Question 9

GABA degradation can also produce

Answer 9

gamma-hydroxybutyrate (GHB)

Question 10

Subunits combine to form

Answer 10

a functional pentameric receptor

Question 11

most common subunits

Answer 11

2 alpha; 2 beta 1 gamma

Question 12

Fast GABAg transmission mediated mainly by

Answer 12

GABAb receptors

Question 13

GABAa receptors are what type of channel

Answer 13

ligand-activated chloride channel

Question 14

GABA (urgent neurons) are related to

Answer 14

seizuers

Question 15

GABAb receptors are central to the modulation of

Answer 15

excitatory and inhibitory synaptic activity

Question 16

GABAb inhibits NT release in terminals through

Answer 16

inhibition of voltage gated Ca channels or hyperpolarizes postsynaptic neurons by activating inwardly rectifying K channels

Question 17

GABAbR are obligatory

Answer 17

heteromers composed of 1 and 2

Question 18

R1 binds agonist with

Answer 18

high affinity

Question 19

R2 mediates coupling to

Answer 19

Galphai

Question 20

GABA has metatropic receptors that are

Answer 20

primarily inhibitory

Question 21

glycine is

Answer 21

from NMDA receptor coagonist

Question 22

glycine responds to

Answer 22

inotropic receptors

Question 23

ligand-gated ion channels are

Answer 23

super family receptors

Question 24

homologous to

Answer 24

GABAa

Question 25

Froms functional

Answer 25

pentameric receptors

Question 26

idoleamine is synthesized from

Answer 26

tyrptophan

Question 27

dopamine is used extensively by CNS for

Answer 27

movement coordination, emotion, and reward/ motivation

Question 28

relatively small pop of DA neurons of

Answer 28

the Substantia Nigra nucleus (SN)

Question 29

Ventral tegmental area innervates

Answer 29

large portion of cortex (hippocampus and limbic system)

Question 30

tyrosine converted by

Answer 30

L-DOPA

Question 31

L-dopa

Answer 31

converted to dopamine

Question 32

vesicle loading aka

Answer 32

vesicular monoamine transporter

Question 33

re-uptake

Answer 33

dopamine transporter (DAT)

Question 34

coke will block

Answer 34

dopamine transporter

Question 35

D1 family

Answer 35

D1 and D5, excitatory

Question 36

D2 family

Answer 36

D2-4, inhibitory

Question 37

D1 family coordination with

Answer 37

glutamate

Question 38

Downstreaming D1 signaling

Answer 38

enhances NMD