Vasculitis Flashcards

1
Q

Systemic Sx

A

Fever
Malaise
Weight loss
Arthralgia / myalgia

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2
Q

Skin Sx

A

Purpura
Ulcers
Lived reticularis - pink / blue mottling
Nail bed infarct

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3
Q

Eye Sx

A

Scleritis
Episcleritis
Visual loss

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4
Q

ENT Sx

A
Epistaxis
Sinusiitis 
Nasal crusting
Stridor 
Deaf
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5
Q

Cardiac Sx

A

Angina
MI
HF
Pericarditis

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6
Q

Resp Sx

A

Haemoptysis
Dyspnoea
Pulmonary haemorrhage
Fibrosis

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7
Q

GI Sx

A

Pain
Perforation
Malabsorption

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8
Q

Renal Sx

A
Hypertension
Haematuria
Proteinuria
Renal casts
Failure
GN ANCA +ve
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9
Q

Neuro Sx

A
Stroke
Seizure
Chorea
Psychosis
Confusion 
Impaired cognition 
Altered mood
CN palsy
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10
Q

GUI Sx

A

Orchitis

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11
Q

Small vessel vasculitis

A

HSP - see paeds
Granulomatis polyangiitis / macroscopic
Microscopic polyangitiis
Eosinophilic (Churg Strauss)

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12
Q

Medium vessel vasculitis

A

Polyarteritis nodosa

Kawasaki - see pads

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13
Q

Large vessel

A

GCA - see ophthalmology

Takayasu - see cardio

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14
Q

Variable vessel

A

Bechet’s

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15
Q

How does granulomatous vessel present and what Ab

A
C-ANCA +Ve with Ab against proteinase 3
Necrotising granulomatous
URTI - epistaxis / sinusitis / deaf / pharyngitis = common
Nasal deformity common  
Very rare without nasal Sx 
LRTI - cough / SOB / haemoptysis 
GN common - Focal necrotising with crescents 
Other features
- Scleritis
- Pericarditis 
- Fever
- Weight loss
- Rash
Higher risk of AKI if colonised with staph
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16
Q

How does microscopic present

A
pANCA +Ve with Ab against myeloperoxidase 
Necrotising vasculitis
No granulomas
Similar presentation 
Lung + kidney 
GN = more common
Pulmonary haemorrhage
17
Q

How does eosinophilic present

A

Necrotising granulomatous
Resp tract
Asthma + eosinophilia
ANCA +ve if GN present

18
Q

Investigation vasculitis

A
FBC, U+E, LFT 
ESR / CRP
ANCA
Urine microscopy
Renal biopsy 
Angiography may be needed
19
Q

What is common presentation

A

Fatigue with raised ESR. /CRP

20
Q

How do you treat

A

Steroids + steroid sparing if large / flare
Immunosuppression for other - cyclophosphamide / methotrexate
Biologics - ritixumab
Plasma exchange if renal failure / anti-GBM
HSP and Kawasaki is different

21
Q

How does polyarteritis present

A
Aneurysms
Thrombosis
Fever / malaise / arthralgia
Weight loss
Lived reticularis rash
Testicular pain
Haematuria / renal failure
22
Q

Who is it common in

A

Hep B

Middle aged men

23
Q

How do you Dx

A

Renal biopsy

24
Q

Bloods

A

Increased WCC / ESR / CRP
Anaemia
ANCA -ve

25
Q

How do you treat

A

Control BP
Steroids
Treat hep B

26
Q

How does Behchet’s present

A
Oral + genital ulcer
Anterior uveitis / retinal haemorrhage 
Thrombophlebitis
DVT
Arthritis
Meningitis 
Abdo pain / diarrhoea / colitis
Erythema nodosum
27
Q

Complications of vasculitis

A

ESRF