Vasculitis Flashcards
Elderly female with unilateral headache, jaw claudication, blindness w/ESR>100?
Temporal (giant cell) arteritis
Temporal (giant cell arteritis) is a disease of branches of which artery?
Granulomatous inflammation of carotid artery
Tx for Temporal arteritis? The tx is to prevent what specific disease?
High Dose corticosteriods=>to prevent blindness
30 y/o Asian Female with weak upper extremity pulses, arthritis, ocular disturbances?
Takayasu Arteritis (pulseless disease)
MOA of Takayasu Arteritis?
Granulomatous Vasculitis of the aortic branches
3 y/o Asian Child who presents with Flu-like symptoms, maculopapular rash on the hands and a red tongue (oral mucositis)?
Think Kawasaki Disease
Symptoms of Kawasaki Disease
Conjunctival Infection, Rash, Adenopathy (Cervical), Strawberry tongue, Hand and foot changes (Edema), Fever (CRASH and Burn)
Most feared complication of Kawasaki Disease?
Crash and Burn the Coronary Arteries (i.e. aneurysms)=>rupture
When is the only time you give aspirin to a kid?
Kawasaki Disease
Young adult with Hx of Hep B infection complains of diffuse pain everywhere but the lungs are spared What will be seen in imaging on this patient? MOA? HSR?
Polyarteritis Nodosa
MOA: Necrotizing vasculitis in all areas except the lungs
HSR: Type 3 HSR
Imaging: String of Pearls appearance
A 35 y/o male with a hx of heavy smoking whose hand blanch white=> then blue and red again?
Buerger’s Disease (thromboangiitis obliterans)
What is the most common complication of Buerger’s Disease?
amputation of digits and phlebitis
A 40 y/o patient with a hx of URI within the past week, chronic sinuitis, hemopytsis and hematuria with red blood cell cast. Dx? Lab finds?
WeCener’s (Granulomatosis with polyangiitis
)c-ANCA/PR3-ANCA;
antiproteinase 3 (third letter of alphabet)
What are triad of symptoms you see in Wegener’s?
Necrotizing Vasculitis/Granulomas of nasopharynx, Lungs and Kidney
Tx of WeCener’s
Cyclophosphamide and Corticosteriods
A 45 y/o white female with hemopytsis and glomerulonephritis is found to have no granulomas. Dx? Lab finds?
Dx: Microscopic Polyangiitis
Labs: mPo-ANCA, P-ANCA
50 y/o female with a one month history of progressive dyspnea, productive cough, pain of elbows and knees, and 40°C fever despite antibiotic treatment. She complains of a wrist drop. She was dx with asthma for 25 years. Dx? Labs?
Eosinophilic granulomatosis with polyangiitis
Labs: P-ANCA, Elevated IgE levels (eosinophilia)
A 5 year old boy complains of stomach hurting. PE shows rash on the buttocks/legs, lower extremity stiffness. Threeweeksago,hesuffered from anupperrespiratoryinfectionwhichhassinceresolved spontaneously. MOA of this disease? What disease is it most associated with?
Henoch-Scholein purpura
MOA: IgA deposition
IgA nephropathy (Berger's disease) Lower extremity stiffness=arthralgia Rash=palpable purpura
Microscopic Polyangiitis vs WeCener’s?
Microscopic Polyangiitis has
- NO granulomas
- No Nasopharyngeal involvement
Henoch-Scholein Purpura has classic triad. What is it?
- Skin=>palpable purpura
- Arthralgias
- GI abdominal pain
30 year old Caucasian female has chewing difficulties and persistent headaches and tenderness over the patient’s temples? Dx?
Takayasu arteritis
30 year old Male asthmatic that develops a wrist drop and has elevated eosinophils. Dx?
Churg-Strauss
7 year old male who has colicky abd. pain, arthralgias and palpable lesion? What is the etiology?
Henoch-Scholein Purpura
Circulating immune complexes
MC vasculitis in kids?
Henoch-Schonlein purpura
White Female with sudden onset of blindness think?
Temporal (giant cell) arteritis
