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Cardiology > Cardiopharmacology > Flashcards

Cardiopharmacology Flashcards

1
Q

Methyldopa

A

MOA: alpha 2 agonistUse: HTN in PregnancyAE: Direct Coombs+ hemolysis, SLE-like syndromeDDI: TCA decreases effects (Direct Opposition)

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2
Q

B-Blockers and MI?

A

Decreases Mortality

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3
Q

B-Blockers in SVT?

A

Metoprolol and esmololClass II anti-arrhythmic

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4
Q

Which B-Blockers are Beta 1 selective?

A

A-M

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5
Q

Which B-Blockers are Non-selective?

A

N-Z

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6
Q

Acebutalol and pindolol

A

MOA: partial B agonistNo change in Blood lipidCan Bronchodilate

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7
Q

Propanolol

A

Use: 1. CNS=>Sedation 2. inhibits deiodination

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8
Q

B-Blockers AE?

A

Cardiovascular depression (Heart Block)Increased LDL and TGs

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9
Q

With B-Blockers, watch out in people with what diseases?

A

Asthma, Vasospastic disorders, DM (masks hypoglycemia)

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10
Q

Hydralazine MOA?

A

MOA: dilates arteries (cGMP smooth muscle relaxation via NO)

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11
Q

Hydralazine AE?

A

AE: SLE-Like Syndrome (high protein binding)

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12
Q

Are Hydralazine and methyl dopa safe to use in pregnancy? What else should be added to these drugs?

A

Yes; Diuretics (HCTZ)

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13
Q

What is DOC IV of Hypertensive emergency?

A

Nitroprusside

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14
Q

Nitroprusside AE? What is the problem with the AE? What can you give together to stop this problem?

A

CN toxicity=>binds to complex 4 of ETCNitrites=>methemoglobinemia Hb (Fe3+)=>binds to CN and releases O2Thiosulfate=>binds to CN

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15
Q

Verapamil/Diltiazem

A

MOA: non dihyropyridine CCB blockers in Heart (verampil=ventricles)AE: Hyperprolactinemia (verapamil) and AV Block, Constipation (verapamil)

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16
Q

Nifedipine and other “dipines” MOA? AE?

A

MOA: Blocks L-type Ca2+ channels in peripheral vascular smooth muscle=>vasodilateAE: Gingival hyperplasia, Raynaud Phenomenon

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17
Q

What drugs can be used in HTN of pregnancy?

A

Hydralazine, Labetalol, methyldopa, nifedipine

18
Q

HTN with DM and HF, DOC?

A

ACE inhibitors and ARBs

19
Q

HTN with Angina and Post MI? DOC?

A

B-Blockers

20
Q

HTN with BPH?

A

Alpha blockers

21
Q

What are the Class IA antiarrhythmics?

A

Quinidine, Procainamide, Disopyramide

22
Q

Quinidine MOA? AE?

A

MOA: Blocks Fast Na+Channels, Increases AP duration and ERPAE: Cinchonism=Headache and tinnitus; Torsades de pointes

23
Q

Procainamide MOA? AE?

A

MOA: Blocks Fast Na+Channels, Increases AP duration and ERPAE: Reversible-SLE like syndrome; Torsades de pointes

24
Q

Disopyramide MOA? AE?

A

MOA: Blocks Fast Na+Channels, Increases AP duration and ERPAE: Heart Failure; Torsades de pointes

25
Q

Class IA antiarrhythmics and digoxin?

A

Displaces digoxin

26
Q

Procainamide MOA? Use? Metabolism? AE?

A

MOA: Blocks Fast Na+Channels, Increases AP duration and ERPUse: WPWMetabolism: N-acetyltransferaseAE: Reversible-SLE like syndrome; Torsades de pointes

27
Q

What are the Class IA antiarrhythmics?

A

Quinidine, Procainamide, Disopyramide

28
Q

Quinidine MOA? AE?

A

MOA: Blocks Fast Na+Channels, Increases AP duration and ERPAE: *Cinchonism=Headache and tinnitus; Torsades de pointes

29
Q

Procainamide MOA? Use? Metabolism? AE?

A

MOA: Blocks Fast Na+Channels, Increases AP duration and ERPUse: WPWMetabolism: N-acetyltransferaseAE: *Reversible-SLE like syndrome; Torsades de pointes

30
Q

Class IA antiarrhythmics and digoxin?

A

Displaces digoxin

31
Q

What are the Class IB antiarrhythmics?

A

Lidocaine, Mexiletine (Buy Liddy some Mexican Tacos)

32
Q

Lidocaine/Mexiletine MOA? AE?

A

MOA: Block inactivated Na+ channels in ischemic tissue=>prevents firing of new action potentials; Blocks Na+ slow window currents=>decreased action potential durationUse: Post MI and Digoxin ToxicityAE: Least CardiotoxicMexiletine=Oral

33
Q

Class IC drugs?

A

Flecainide and Propafernone

34
Q

Flecainide/Propafernone

A

MOA: Blocks all Na+ channelsProarrhythmic (contraindicated in ischemic heart disease)

35
Q

B-Blockers MOA?

A

Decrease SA and AV nodal activity by?cAMP,?Ca2+ currents=>decreases slope 4

36
Q

Class 3 antiarrhythmics?

A 
AIDS
Amiodarone
Ibutilide
Dofetilide
Sotalol
37
Q

Class 3 MOA?

A

Prolongs repolarization

38
Q

Amiodarone AE?

A

Pulmonary Fibrosis
Blue Skin
Blue corneal deposits
Blue=>iodine=>hyperthyroidism

39
Q

Sotalol, Ibutilide AE?

A

Torsades De Pointes

40
Q

Verapamil, Diltiazem MOA?

A

Decreases conduction velocity

Cardiology (12 decks)

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