Lipid Lowering Agents

Question 1

Statins MOA? Accumulation of?

Answer 1

Inhibit conversion of HMG- CoA to mevalonate=>Decreased LDL

HMG- CoA

Question 2

Statins AE?

Answer 2

AE: Hepatotoxicity and decreased ATP=>myopathy

Question 3

Bile acid Resins (cholestyramine, colestipol) MOA?

Answer 3

MOA: Prevent intestinal reabsorption of bile acids=>upregulation of LDL receptors=>Decreased LDL

Question 4

Bile acid Resins AE?

Answer 4

1. Hypertriglyceride

2. Decreased absorption of drugs and FAT soluble vitamins (like Vit. K)

Question 5

Ezetimibe MOA?

Answer 5

Prevent cholesterol absorption at small intestine=>Decreased LDL

Question 6

Fibrates (Gemfirbrozil) MOA?

Answer 6

MOA: Upregulate Lipoprotein lipase=> increased TG clearance=> decreased TG

Activates PPAR=>increase HDL

Question 7

Fibrates AE?

Answer 7

Gallstones

Question 8

Niacin MOA?

Answer 8

Inhibits lipolysis=>increased HDL

Question 9

Niacin AE? AE is blocked with?

Answer 9

Flushing via PGE; blocked with NSAIDs