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Cardiovascular - step > Vasculitis > Flashcards

Vasculitis Flashcards

1
Q

unilateral headache
jaw claudication
polymyalgia rheumatica

A

temporal arteritis

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2
Q

what vessels affected in temporal arteritis

A

branches of the carotid artery

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3
Q

consequences of temporal arteritis

A

irreversible blindness

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4
Q

treatment of temporal arteritis

A

corticosteroids before biopsy

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5
Q

what will you see on biopsy of temporal arteritis

A

focal granulomatous inflammation

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6
Q

lab in large vessel vasculitis

A

increased ESR

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7
Q

elderly females

A

temporal arteritis

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8
Q 
weak upper extremity pulses
fever
night sweats
arthritis
myalgias
skin nodules
ocular disturbances
A

takayasu artertis

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9
Q

Asian feamles < 40 yp

A

takayasu arteritis

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10
Q

histo on takayasu arteritis

A

granulomatous thickening and narrowing of arotic arch and proximal great vessels

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11
Q

tx of takayasu arteritis

A

corticosteroids

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12
Q

hepatitis B seropositivity

A

polyarteritis nodosa

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13
Q 
fever
weight loss
malaise
headache
abdominal pain
melena
hypertension
neurologic fysfunction
cutaneous eruptions
renal damage
A

polyarteritis nodosa

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14
Q

young adults mainly men

A

polyarteritis nodosa

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15
Q

vessels affected in polyarteritis nodosa

A

renal, visceral

not pulmonary arteries

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16
Q

polyarteritis nodosa is what type of immune response

A

type III hypersensitivity

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17
Q

histo in polyartertis nodosa

A

transmural inflammation of arterial wall with fibirinoid necrosis
at ALL stages of inflammation

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18
Q

treat of polyarteritis nodosa

A

corticosteroids, cyclophosphamde

19
Q

Asian children < 4 yo

A

Kawasaki disease

20
Q 
conjunctival injection
rash - polymorphous/desquamating
cervical adenopathy
oral ucositis/strawberry tongue
hand/foot changes - edema erythema
fever
A

Kawasaki disease

21
Q

complication of Kawasaki disease

A

coronary artery aneurysm, thrombosis, rupture can cause death

22
Q

treatment of Kawasaki disease

A

IVIG

aspirin

23
Q

heavy smokers, malesl < 40 yo

A

buerger disease

thromboangiitis obliterans

24
Q

intermittent claudication may lead to gangreme, autoamputatio of digits, superficial nodular phlebitis

A

beurger disease

thromboangiitis obliterans

25
Q

histpath in thromboangiitis obliterans

A

segmental thrombosing vasculiitis

26
Q

treatment of buerger disease

A

smoking cessation

27
Q

perforation of nasal septum, chronic sinusitis, otitis media, mastoiditis

hemoptysis, cough, dyspnea

hematuria, red cell cast

A

franulomatosis with polyangiitis/wegener

28
Q

triad of histopath in wegener

A

focal necrotizing vascultis
necrotozing granulomas in lung and upper airway
necrotoxing glomerulonephritis

29
Q

PR3-ANCA/c-ANCA/anti-proteinase3

A

Wegener/granulomatosis with polyangiitis

30
Q

CXR with large nodular densities

A

Wegener/granulomatosis with polyangiitis

31
Q

treatment of wegener

A

cyclophosphamide and corticosteroids

32
Q

no nasopharyngeal invovlemtn @ lungs, kidney, skin, kidney, palpable purpura

A

microscopic polyangiitis

33
Q

no granulomas!!!

A

microscopic polyangiitis

34
Q

MPO-ANCA/p-ANCA/anti-myeloperoxidase

A

microscopic polyangiitis, churg strauss (also increased IgE)

35
Q 
asthma
sinusitis
skin nodules
purpura
peripheral neuropathy
A

eusinophilic granulomatosis with polyangiitis (churg-strauss)

36
Q

heart
gi
kidness

A

churg strauss

37
Q

histopath in eosinophilic granulomatosis with polyangiitis/churg-strauss

A

granulomatous necrotizing vasculitis with eosionphilila

38
Q

treatment of microscopic polyangiitis

A

cyclophosphamide

corticosteroids

39
Q

palpable purpura on buttocks/legs
arthralgias
abdominal pain

A

Henoch-Schonlein purpura

40
Q

vasculitis following a URI

A

Huenoch Schonlein purpura

41
Q

pathogenesis in Henoch Schonlein purpura

A

vasculitis secondary to IgA immune complexes

42
Q

what is Henoch Schonelein purpura asosociated with

A

IgA nephropathy/Berger diseas

43
Q

what type of immune reaction is Henoch Schonlein purpura?

A

Type III hypersensitivity

Cardiovascular - step (8 decks)

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