Vasculitides

Question 1

asthma + skin/purpura + peripheral neuropathy + heart + GI + kidneys

Answer 1

eosionophilic granulomatosis

Question 2

lungs, kidneys, skin

no nose

Answer 2

microsopic polyangiitis

Question 3

high IgE level + granulomas

Answer 3

eosionophilic granulomatosis

Question 4

segmental transmural inflammation of mid-sized arteries

Answer 4

polyarteritis nodosa

Question 5

hepatitis (esp. B)

Answer 5

polyarteritis nodosa

Question 6

IgA nephropathy (hematuria, mesangial prolfieration)

Answer 6

Henoch-Schonlein

Question 7

young adults + HTS + abdominal pain with melena + CNS + skin + any organ + weight loss + fever

Answer 7

polyarteritis nodosa

Question 8

1. focal necrotizing vasculitis
2. necrotizing granulomas in LUNG + UPPER AIRWAY (nose, soft palate, oropharynx, sinus)
3. necrotizing glomerulonephritis

Answer 8

granulmatosis with polyangiitis (GPA)/Wegener

Question 9

lungs, kidneys, upper airway

Answer 9

granulmatosis with polyangiitis (GPA)/Wegener

Question 10

asthma + sinusitis + peripheral neuropathy + skin

Answer 10

eosinophilic granulomatosis with polyangiitis

Question 11

associated with Hep B

Answer 11

polyarteritis nodosa

Question 12

TX for polyarteritis nodosa + GPA + MPA (microscopic)

Answer 12

steroids

cyclophosphamide

Question 13

medium (3)

Answer 13

poyarteritis nodosa
Kawasaki
Buerger/thromboangiitis obliterans

Question 14

large (2)

Answer 14

temporal giant cell arteritis

Takayasu

Question 15

different stages of inflammation in different BV + transmural inflammation + fibrinoid necrosis

Answer 15

polyarteritis nodosa

Question 16

granulomatous inflammation of media

IEL fragmentation

Answer 16

giant cell arteritis

Question 17

palpable purpura + arthralgia + GI pain (intussusception) + kidney disease

Answer 17

IgA/Henoch-Schonlein

Question 18

visceral organs –> skin, kidney, GI, heart

middle-aged men

Answer 18

polyarteritis nodosa

Question 19

pauci-immune GN

Answer 19

microsopic polyangiitis (p-ANCA)
eosinophilic (p-ANCA)

Question 20

small (4)

Answer 20

granulmatosis with polyangiitis (GPA)/Wegener
microscopic polyangiitis (MPA)
eosinophilic granulomatosis with polyangiitis (Churg-Strauss)
Henoch-Schonlein purpura

Question 21

URI: perforated nasal septum, saddle nose, sinusitis
LRI: hemoptysis, cough, SOB
kidney: hematuria, RBC casts

Answer 21

granulmatosis with polyangiitis (GPA)/Wegener

Question 22

Behcet syndrome

Answer 22

• Turkish, eastern Mediterraneon
• aphthous ulcers, genital, uveitis, rash
• precipitated by HSV, parvovirus
• HLA-B51

Question 23

aortic arch at branch points

Answer 23

Takayasu

“aaa”

Question 24

fibrinoid necrosis (eosin-staining wall)

Answer 24

polyarteritis nodosa

Question 25

pulseless, weak/absent in UPPER extremity + high ESR

Answer 25

Takayasu

Question 26

polymyalgia rheumatica

Answer 26

giant cell arteritis

Question 27

HA, carotid artery, jaw claudication, polymyalgia rheumatica

-elevated ESR

Answer 27

temporal giant cell arteritis

Question 28

smoking + ulceration + fingers/toes autoamputatoin, Raynaud

Answer 28

thromboangiitis obliterans/Buerger

Question 29

multisystemic, but spares lungs

Answer 29

polyarteritis nodosa

Question 30

TX for temporal giant cell arteritis (or risk ___)

Answer 30

steroids

blindness

Question 31

vasculitides with p-ANCA

Answer 31

microsopic polyangiitis

eosionophili granulomatosis

Question 32

vasculitides with c-ANCA

Answer 32

GPA/Wegener

Question 33

palpable purpura + weakness + arthralgias

peripehral neuropathy
renal disease

Answer 33

mixed cryoglobuilnemia (deposits IgG and IgA complexes)

Question 34

cutaneous small BV vasculitis

Answer 34

1 week after meds (penicillin, cephs, phenytoin, allopurinol) or infections (Hep, HIV)

Question 35

vasculitides with p-ANCA

Answer 35

microsopic polyangiitis

eosionophilic granulomatosis

Question 36

most common systemic vasculitis in kids

Answer 36

Henoch-Schonlein

Question 37

circulating IgA complexes

Answer 37

Henoch-Schonlein