Glomerular Diseases Flashcards
causes of membranous nephropathy
primary: Ab to PLP A2 receptor (IgG)
secondary: drugs (NSAIDS, penicillamine, gold), infection (Hep, syphilis), SLE, tumours
subENDOthelial humps (2)
- diffuse PROLIFERATIVE
- membranoPROLIFERATIVE GN
ENDO = PROLIFERATIVE
nephrotic diseases
- diabetic nephropathy
- FSGS
- minimal change
- membranous nephropathy
- amyloidosis
nephrotic syndrome
- proteinuria!!
- low albumin
- edema
- low antithrombin
- risk of infection
- high lipids (liver makes them to increase oncotic pressure)
- frothy urine
efface peodocytes
minimal change
FSGS
types of RPGN
1: anti-GBM (linear): Goodpasture
2: immune complex (lumpy bumpy)
3: pauci-immune (NO Ig or complement) - with C-ANCA or p-ANCA
spike and dome
membranous nephropathy (subepithelial)
GRANULAR immune complex (3)
- membranous nephropathy
- post-strep GN
- diffuse proliferative (SLE)
p-ANCA
RPGN + microscopic polyangiitis
most common nephrotic syndrome in AA and Hispanics
FSGS
subEPIthelial humps (2)
- membranous nephropathy
- post-strep GN
both nephritis + nephrotic
- diffuse PROLIFERATIVE GN (SLE)
- membranoPROLIFERATIVE GN
IgG/IgM immune complexes (LOW complement levels) (4)
RPGN
post-strep GN
diffuse proliferative GN (SLE)
MPGN
nephritic syndrome
- light proteinuria
- hematuria
- RBC casts
- azotemia (BUN, Cr increased)
- oliguria
wire loops
diffuse proliferative (SLE)
deposit fibrin
Goodpasture (RPGN crescent)
pharynx or skin infection
post-strep GN
fibrin
RPGN
triggers of minimal change disease
infection immunization immune stimulus insect bit NSAID
nephritic diseases
- post-strep GN
- RPGN
- membranoproliferative GN
- IgA nephropathy
- Alport
tram track
MPGN (mesangium grows in between BM)
C1q
MPGN
c-ANCA
RPGN + GPA (Wegener)
basket-weave
Alport
LINEAR immune complex (1)
RPGN/crescent/Goodpasture
type I: anti-GBM
peripheral, periorobital edema, tea urine, HTN
acute poststrep GN
lumpy bumpy in mesangium
post-strepGN
can’t see cant pee cant hear a bee
alport (x-linked)
NORMAL complement level (and immune complex deposition)
IgA nephropathy
RPGN crescents are made of
fibrin plasma proteins glomerular perital cells monocytes m-phages
types of MPGN
type I: Hep B, C, SLE, subacute bacterial endocarditis (subENDOthelial deposits)
type II: C3 nephritic factor (deposit in membrane)
tramtrack –> mesangial grows in between BM
Ab to GBM
GOodpasture
mesangium (2)
- IgA nephropathy
- diabetic neprhopathy
affects BM (3)
- MEMBRANous nephropathy
- MEMBRANOproliferative GN MPGN)
- diabetic nephropathy (thick GBM)
respiratory or GI infection, or spontaneous
IgA nephropathy
segmental sclerosis + hyalinosis
FSGS
Hep B, C
MPGN
subacute bacterial endocarditis
MPGN
PLP A2
membranous nephropathy
penicillamine, NSAIDs
membranous nephropathy
SLE (not diffuse SLE)
membranous nephropathy
