Heme Flashcards
target cells
increased SA: vol
RBC folds on itself
HALT
- HbC disease (strucutral mutation)
- asplenia (can’t get rid of RBC)
- liver disease (cholesterol > phospholipid, so excess RBC cell membrane)
- thalassemia (smaller cell volume because less Hb)
echinocytes (burr cell)
regular spikes
pyruvate kinase deficiency end stage kidney disease liver disease uremia hemolytic anemia mechanical damage
peripheral smear: basophilic stippling
aggregation of ribo precipitates (NOT Fe)
sideroblastic anemia
- Pb poisoning
- myelodysplastic syndromes
thalassemia
elliptocytes
hereditary ellipocytosis
spherocytes
hereditary spherocytosis
infection-induced hemolytic anemia
Howell-Jolly bodies
nuclear remnants in RBC –> only 1 per cell
no spleen
acanthocytes/spur cells
irregular spikes
abetalipoproteinemia
liver disease
dacrocyte (teardrop)
BM infiltration (--> myelofibrosis) thalassemia
*RBC sheds a tear b/c it’s squeezed out of it’s home in BM
macro-ovalocytes
megaloblastic anemia
schistocytes
microangiopathic hemolytic anemias
- DIC
- TTP/HUS
- HELLP syndrome
- mechanical hemolysis
Pappenheimer bodies
Fe granules
sideroblastic anemia
myelodysplastic syndromes
stem cell disorders involving ineffective hematopoiesis
-defective cell maturation of non-lymphoid lineages
-risk transforming to AML
degmacyte (bite or basket cell)
-due to removal of Heinz bodies by splenic m-phages
G6PD def
BM smear with Prussian blue: ringed sideroblasts
excess Fe in mito
sideroblastic anemia
- drugs
- chronic alcohol
- myelodysplastic syndrome
Heinz bodies
(Fe + oxidized, precipitated Hb) –> can have multiple
G6PD def
smudge cells
CLL
aplastic anemia
pancytopenia with BM hypocellularity
- FATTY infiltratoin
- NO splenomegaly (NO extramedullary hematopoiesis because no hematopietic progenitor cells)
-HbC disease (strucutral mutation)
target cell
-asplenia (can’t get rid of RBC)
target cell
-liver disease (cholesterol > phospholipid, so excess RBC cell membrane)
target cell
-thalassemia (smaller cell volume because less Hb)
target cell
pyruvate kinase deficiency
ecchinocyte (regular spike)
end stage kidney disease
ecchinocyte (regular spike)
liver disease
ecchinocyte (regular spike)
uremia
ecchinocyte (regular spike)
hemolytic anemia
ecchinocyte (regular spike)
mechanical damage
ecchinocyte (regular spike)
HELLP
schistocytes
